| Proje Ekibi |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye Projedeki Rolü: Araştırmacı |
| Proje Türü | Diğer Uluslararası Kurum ve Kuruluşlar |
| Proje No | - |
| Proje Konusu | Prolactin has well over 300 known functions in vertebrates It regulates virtually every aspect of physiology including osmoregulation behavior growth and metabolism reproduction and immune function The investigators will address the novel mechanisms by which the steroid cortisol rapidly inhibits prolactin release from the pituitary gland of an important euryhaline food fish the tilapia Oreochromis mossambicus The first objective will address the type of receptor that cortisol may bind to rapidly modulate prolactin secretion The second will examine whether the steroid acts to rapidly alter the membrane electrical properties of prolactin cells to reduce voltage sensitive calcium channels either directly or through increasing potassium ion conductances across the cell membrane The third aim will test whether cortisol inhibits phospholipase C activity inositol triphosphate production calcium release from intracellular sensitive pools and activity of protein kinases in events that lead to rapid reductions in prolactin release The fourth objective will explore whether the steroid might rapidly modify growth factor signaling to regulate prolactin release These studies will employ a combination of methods to study cell signaling including both cell and tissue culture pharmacological manipulations bioimaging hormone receptor binding immunoassays and electrophysiology |
| Proje Durumu | Tamamlandı |
| Başlangıç Tarihi | 15-09-2002 |
| Bitiş Tarihi | 31-08-2007 |
