| Proje Ekibi |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye Projedeki Rolü: Araştırmacı |
| Proje Türü | (Uluslararası) Diğer Uluslararası Kurum ve Kuruluşlar |
| Proje No | - |
| Proje Konusu | A fundamental observation in oncology is that the rate of malignancies increases significantly as a function of age suggesting a potential mechanistic link between the cellular process governing longevity and the development of cancers In this regard the genes that play a critical role in longevity or aging have recently been characterized in Saccharomyces cerevisiae and C elegans and the human homologs of these genes are referred to as the Sirtuin gene family Thus we hypothesized that the sirtuin genes might function as fidelity genes and loss sirtuin function which might occur during aging would create cellular environment permissive for age related illness including carcinogenesis To address this idea we constructed mice four years ago that have the mitochondrial localized SIRT3 protein genetically deleted Thus we hypothesize that agents thought to prevent the cellular effects of aging and the accumulation of intracellular ROS such as CR will be prevent tumors in the SIRT3 knockout mice |
| Proje Durumu | Tamamlandı |
| Başlangıç Tarihi | 01-09-2011 |
| Bitiş Tarihi | 01-09-2016 |
