| Proje Ekibi |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye Projedeki Rolü: Araştırmacı |
| Proje Türü | Diğer Uluslararası Kurum ve Kuruluşlar |
| Proje No | - |
| Proje Konusu | Nuclear genome instability a hallmark of cancer is thought to be an early event in tumorigenesis including malignancies induced from IR either from incidental exposure or secondary to therapy It is well established that mammalian cells contain fidelity proteins that appear to protect against both endogenous and exogenous forms of genotoxic stress including ionizing radiation IR induced genomic instability This idea is based on one of the fundamental paradigms in biology that is mammalian cells contain fidelity proteins that recognize specific conditions including cell damage and subsequently initiate signaling cascades that maintain cellular homeostatic poise In this proposal we hypothesize that SIRT3 protects against IR induced genomic instability and carcinogenesis via the regulation of MnSOD activity and the post translation modification of a reversible acetyl lysine To investigate a mechanistic connection between SIRT3 MnSOD and IR induced genomic instability a series of in vitro and in vivo model systems will be used |
| Proje Durumu | Tamamlandı |
| Başlangıç Tarihi | 07-07-2010 |
| Bitiş Tarihi | 31-12-2014 |
