| Proje Ekibi |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye Projedeki Rolü: Yürütücü |
| Proje Türü | (Uluslararası) Diğer Uluslararası Kurum ve Kuruluşlar |
| Proje No | - |
| Proje Konusu | Activin is a growth suppressive ligand of the TGF superfamily It initiates its canonical signaling via a specific receptor activin receptor 2 ACVR2 that subsequently phosphorylates activin receptor 1 ACVR1 to activate a signaling cascade culminating in nuclear translocation of SMAD proteins and growth suppression We have data showing that ACVR2 protein is lost by distinct mechanisms in human colon cancer regardless of the type of genomic instability and loss is associated with an increase in tumor size in primary colon cancer specimens The goal of this project is to analyze the effects of loss of SMAD dependent versus SMAD independent activin signaling on colon cancer characteristics and patient outcomes as well as to dissect mechanisms of activin s distinct effects on migration and cell growth We hypothesize that mutated ACVR2 interrupts activin signaling causing increased colon cancer cell growth via loss of SMAD dependent signaling but a decrease in metastatic phenotype via loss of SMAD independent signaling This project assesses the specific role of activin signaling and ACVR2 on colon cancer cell growth and migration using human specimens cellular and in vivo models |
| Proje Durumu | Tamamlandı |
| Başlangıç Tarihi | 27-09-2010 |
| Bitiş Tarihi | 27-09-2015 |
