| Yazarlar |
Mesut Işık
Bilecik Şeyh Edebali Üniversitesi, Türkiye |
|
Abdullah Tunç
Türkiye |
Doç. Dr. Hatice Esra DURAN
Kafkas Üniversitesi, Türkiye |
|
Muhammet Emin Naldan
Türkiye |
|
Aslan Yılmaz
Türkiye |
|
Mehmet Nuri Koçak
Türkiye |
|
Şükrü Beydemir
Anadolu Üniversitesi, Türkiye |
| Özet |
| It is known that oxidative stress originating from reactive oxygen species plays a role in the pathogenesis of Alzheimer's disease. In this study, the role of antioxidant status associated with oxidative stress in Alzheimer's disease was investigated. Peripheral blood samples were obtained from 28 healthy individuals (as control) and 28 Alzheimer's patients who met the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association criteria. Catalase, glutathione S-transferase and paraoxonase 1 enzyme activities in blood plasma and glutathione S-transferase enzyme activities in erythrocytes were determined by spectrophotometer. Catalase, glutathione S-transferase and presenilin 1 gene expressions in leukocytes were determined using qRT-PCR. Data were analysed with SPSS one-way anova, a LSD post hoc test at p < 0.05. The activity of each enzyme was significantly reduced in Alzheimer's patients compared to control. The catalase gene expression level did not change compared to the control. Glutathione S-transferase and presenilin 1 gene expression levels were increased compared to the control. |
| Anahtar Kelimeler |
| Alzheimer's disease | antioxidant status | enzyme activity | gene expression | paraoxonase 1 | presenilin 1 |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE |
| Dergi ISSN | 1582-1838 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 11-2023 |
| Cilt No | 27 |
| Sayı | 21 |
| Sayfalar | 3388 / 3394 |
| Doi Numarası | 10.1111/jcmm.17953 |
| Makale Linki | http://dx.doi.org/10.1111/jcmm.17953 |
| Atıf Sayıları | |
| WoS | 2 |
| Google Scholar | 1 |
