Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors
Yazarlar (8)
Doç. Dr. Nebih Lolak Adıyaman Üniversitesi, Türkiye
Doç. Dr. Süleyman Akocak Adıyaman Üniversitesi, Türkiye
Prof. Dr. Mustafa Durgun Harran Üniversitesi, Türkiye
Doç. Dr. Hatice Esra DURAN Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Adem Necip Türkiye
Prof. Dr. Cüneyt Türkeş Erzincan Binali Yıldırım Üniversitesi, Türkiye
Prof. Dr. Mesut Işık Bilecik Şeyh Edebali Üniversitesi, Türkiye
Prof. Dr. Şükrü Beydemir Anadolu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | MOLECULAR DIVERSITY (Q2) | ||
| Dergi ISSN | 1381-1991 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2023 |
| Kabul Tarihi | 09-09-2022 | Yayınlanma Tarihi | 22-09-2022 |
| Cilt / Sayı / Sayfa | 27 / 4 / 1735–1749 | DOI | 10.1007/s11030-022-10527-0 |
| Makale Linki | http://dx.doi.org/10.1007/s11030-022-10527-0 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| To discover alternative substances to compounds used to treat many diseases, especially treating Alzheimer’s disease (AD) and Parkinson’s disease targeting carbonic anhydrase (hCA) and acetylcholinesterase (AChE) enzymes, is important. For this purpose, a series of novel bis-ureido-substituted sulfaguanidine (SG1–4) and sulfisoxazole (SO1–4) derivatives were synthesized, and their inhibitory capacities were screened against hCA isoenzymes (hCA I and II) and AChE. Possible binding mechanisms of inhibitors to the active site were elucidated by in silico studies, and the results were supported by in vitro results. Moreover, the percent radical scavenging capacities of the derivatives were also evaluated. The derivatives (SG1–4 and SO1–4) were more effective against hCAs compared to standard drug acetazolamide (KI values of 98.28–439.17 nM for hCA I and II, respectively) and exhibited the highest … |
| Anahtar Kelimeler |
| Carbonic anhydrase | Acetylcholinesterase | Molecular docking | Sulfaguanidine | Sulfisoxazole |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 56 |
| Google Scholar | 61 |