Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases
Yazarlar (1)
Doç. Dr. Hatice Esra DURAN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (Q2) | ||
| Dergi ISSN | 0885-4513 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 02-2023 |
| Kabul Tarihi | 18-01-2022 | Yayınlanma Tarihi | 23-02-2022 |
| Cilt / Sayı / Sayfa | 70 / 1 / 68–82 | DOI | 10.1002/bab.2329 |
| Makale Linki | http://dx.doi.org/10.1002/bab.2329 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Alzheimer's disease (AD) is a neurodegenerative disorder. The disease is characterized by dementia, memory impairment, cognitive impairment, and speech impairment. Cholinesterases (ChEs; AChE, acetylcholinesterase and BChE, butyrylcholinesterase) inhibitors and their benefits of cholinergic replacement in the treatment of AD have been researched and documented by scientists in various ways to date. Recent studies prove that human carbonic anhydrases (hCAs) are also one of the important targets in the treatment of AD. Therefore, the development of new agents that can simultaneously modulate the various mechanisms or targets involved in the AD pathway may be a powerful strategy to treat AD, the current disease. Considering these data, the effects of the pyrimidines (1–7) were investigated in this study for the discovery and development of multitargeted ChEs and hCAs inhibitors associated with AD … |
| Anahtar Kelimeler |
| biological activity | enzymes | inhibition | molecular docking | pyrimidine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 8 |
| Google Scholar | 12 |