| Yazarlar |
Parham Taslımı
Türkiye |
|
Yeliz Demir
Ardahan Üniversitesi, Türkiye |
Doç. Dr. Hatice Esra DURAN
Kafkas Üniversitesi, Türkiye |
|
Ümit Muhammet Koçyiğit
Türkiye |
|
Burak Tüzün
Türkiye |
|
Osman Nuri Aslan
Türkiye |
|
Mustafa Ceylan
Türkiye |
|
İlhami Gülçin
Atatürk Üniversitesi, Türkiye |
| Özet |
| Utilizing the simple chromatic techniques, Aldose reductase (AR) was derived from sheep liver. In addition, α-glycosidase from Saccharomyces cerevisiae was used as the enzyme. It was determined the interactions between compounds and the enzymes. Molecular docking method used to compare biological activity values of molecules against enzymes. In the current study, the inhibition effect of synthetic isoindol-substitute thiazole derivatives (3a-f) on AR, and α-glycosidase enzymes was studied. In the thiazole series, compound 3b (Ki: 9.70±4.72 M) showed a maximum inhibitory impact towards AR while compound 3f (Ki: 44.40±17.18 M) showed a lowest inhibitory impact towards AR. It was investigated potent inhibition profiles with Ki values in the range of 24.54±6.92–44.25±10.34 M against α-glycosidase. Theoretical results were found consistent with experimental results. Acting as antidiabetic agents, these compounds have the potential to be the selective inhibitor of α-glycosidase and AR enzymes. The biological activities of the studied molecules against AR and α-glycosidase enzymes will be compared with molecular docking method. ADME analysis of the molecules will be done. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | Cumhuriyet Science Journal |
| Dergi ISSN | 2587-2680 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | Türkçe |
| Basım Tarihi | 09-2021 |
| Cilt No | 42 |
| Sayı | 3 |
| Sayfalar | 553 / 564 |
| Doi Numarası | 10.17776/csj.897800 |
| Makale Linki | http://dx.doi.org/10.17776/csj.897800 |
| Atıf Sayıları | |
| Google Scholar | 4 |
