| Yazarlar |
Yeliz Demir
Ardahan Üniversitesi, Türkiye |
Doç. Dr. Hatice Esra DURAN
Kafkas Üniversitesi, Türkiye |
|
Lokman Durmaz
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Parham Taslımı
Türkiye |
|
Şükrü Beydemir
Anadolu Üniversitesi, Türkiye |
|
İlhami Gülçin
Atatürk Üniversitesi, Türkiye |
| Özet |
| Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common and debilitating consequence of a lot of disorders and diseases. The management of chronic pain is particularly challenging. For pain treatment, many analgesic drugs are used for their therapeutic effects. In this study, some nonsteroidal anti-inflammatory drugs including etofenamate, meloxicam, diclofenac, and tenoxicam were tested against α-glycosidase from Saccharomyces cerevisiae, sorbitol dehydrogenase (SDH), and aldose reductase (AR) enzymes from sheep liver. Nonsteroidal anti-inflammatory drugs demonstrated useful inhibition properties against α-glycosidase, AR, and SDH enzymes. K values were found in the range of 11.93 ± 3.77-364.88 ± 40.01 μM for α-glycosidase, 3.36 ± 1.08μM-17.68 ± 3.39 mM for AR, and 1.68 ± 0.02 μM-30.98 ± 14.31 mM for SDH. They can be selective drugs as antidiabetic agents, because of their inhibitory properties against SDH, α-glycosidase, and AR enzymes. |
| Anahtar Kelimeler |
| Nonsteroidal anti-inflammatory drugs | Enzyme inhibition | alpha-Glycosidase | Aldose reductase | Sorbitol dehydrogenase |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY |
| Dergi ISSN | 0273-2289 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2020 |
| Cilt No | 190 |
| Sayı | 2 |
| Sayfalar | 437 / 447 |
| Doi Numarası | 10.1007/s12010-019-03099-7 |
| Makale Linki | http://link.springer.com/10.1007/s12010-019-03099-7 |
| Atıf Sayıları | |
| WoS | 54 |
| Google Scholar | 60 |
