The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and α-Glycosidase: a Perspective for Metabolic Disorders
Yazarlar (6)
Prof. Dr. Yeliz Demir Ardahan Üniversitesi, Türkiye
Doç. Dr. Hatice Esra DURAN Kafkas Üniversitesi, Türkiye
Doç. Dr. Lokman Durmaz Erzincan Binali Yıldırım Üniversitesi, Türkiye
Doç. Dr. Parham Taslımı Türkiye
Prof. Dr. Şükrü Beydemir Anadolu Üniversitesi, Türkiye
Prof. Dr. İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (Q3) | ||
| Dergi ISSN | 0273-2289 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2020 |
| Kabul Tarihi | 18-07-2019 | Yayınlanma Tarihi | 05-08-2019 |
| Cilt / Sayı / Sayfa | 190 / 2 / 437–447 | DOI | 10.1007/s12010-019-03099-7 |
| Makale Linki | http://link.springer.com/10.1007/s12010-019-03099-7 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common and debilitating consequence of a lot of disorders and diseases. The management of chronic pain is particularly challenging. For pain treatment, many analgesic drugs are used for their therapeutic effects. In this study, some nonsteroidal anti-inflammatory drugs including etofenamate, meloxicam, diclofenac, and tenoxicam were tested against α-glycosidase from Saccharomyces cerevisiae, sorbitol dehydrogenase (SDH), and aldose reductase (AR) enzymes from sheep liver. Nonsteroidal anti-inflammatory drugs demonstrated useful inhibition properties against α-glycosidase, AR, and SDH enzymes. Ki values were found in the range of 11.93 ± 3.77–364.88 ± 40.01 μM for α-glycosidase, 3.36 ± 1.08μM–17.68 ± 3.39 mM for AR, and 1.68 ± 0.02 μM–30.98 ± 14.31 mM for SDH. They can be selective drugs as … |
| Anahtar Kelimeler |
| Nonsteroidal anti-inflammatory drugs | Enzyme inhibition | alpha-Glycosidase | Aldose reductase | Sorbitol dehydrogenase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 63 |
| Google Scholar | 71 |