Inhibition effects of quinones on aldose reductase: Antidiabetic properties
Yazarlar (5)
Prof. Dr. Yeliz Demir Ardahan Üniversitesi, Türkiye
Doç. Dr. Muhammet Serhat Özaslan Ardahan Üniversitesi, Türkiye
Doç. Dr. Hatice Esra DURAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Ömer İrfan Küfrevioğlu Atatürk Üniversitesi, Türkiye
Prof. Dr. Şükrü Beydemir Anadolu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Environmental Toxicology and Pharmacology (Q2) | ||
| Dergi ISSN | 1382-6689 Dergi Bilgileri (2019) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-08-2019 |
| Cilt / Sayı / Sayfa | 70 / 0 / 103195– | DOI | 10.1016/j.etap.2019.103195 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S1382668919300626 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a glucose reducing agent and is involved in the pathophysiology of diabetic complications. In this study, we purified AR from sheep kidney with a specific activity of 2.00 EU/mg protein and 133.33- fold purification After the purification of the AR enzyme, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was performed and the molecular weight of the enzyme was found approximately as 38 kDa. The inhibition effects of eight quinones were studied against AR. The quinones were potent inhibitors of AR with Ki values in the range of 0.07–20.04 μM. Anthraquinone showed the best potential inhibitory effects against AR. All compounds exhibited noncompetitive inhibition against AR … |
| Anahtar Kelimeler |
| Aldose reductase | Diabetes | Inhibition | Purification | Quinones |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 83 |