Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
Yazarlar (8)
Doç. Dr. Hatice Esra DURAN Türkiye
Yeliz Demir Ardahan Üniversitesi, Türkiye
Necla Öztaşkın
Ahmet Maraş Atatürk Üniversitesi, Türkiye
İlhami Gülçin Atatürk Üniversitesi, Türkiye
Şükrü Beydemir Anadolu Üniversitesi, Türkiye
Süleyman Göksu Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (Q1) | ||
| Dergi ISSN | 0141-8130 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2018 |
| Cilt / Sayı / Sayfa | 119 / 0 / 857–863 | DOI | 10.1016/j.ijbiomac.2018.08.004 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0141813018328460 | ||
| Özet |
| Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol pathway. α-Glycosidase and α-amylase are important enzymes in glucose metabolism. In this study, AR was purified from purified from cow liver. The enzyme was obtained with 139.17 purification fold and with a specific activity of 1.67 EU/mg protein. Then, it is observed the inhibition effect of diarylmethanons (1a–d), bromophenols (2a–d and 4a–d) and diarylmethanes (3a–d) on aldose reductase, α-glycosidase and α-amylase enzymes. In these series, compound 2a showed lowest inhibitory activity against AR with a Ki value of 1.09 ± 0.29 μM while compound 2d showed highest inhibitory activity against AR with a Ki value of 0.092 ± 0.015 μM. Additionally, α-glycosidase and α-amylase … |
| Anahtar Kelimeler |
| alpha-Amylase | alpha-Glycosidase | Aldose reductase | Bromophenols | Diarylmethanons |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 217 |
| Web of Science | 193 |