Oxidative stress and mRNA expression of acetylcholinesterase in the leukocytes of ischemic patients
Yazarlar (6)
Mesut Işık Harran Üniversitesi, Türkiye
Şükrü Beydemir Anadolu Üniversitesi, Türkiye
Muhammet Emin Naldan
Doç. Dr. Hatice Esra DURAN Türkiye
İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BIOMEDICINE & PHARMACOTHERAPY (Q1) | ||
| Dergi ISSN | 0753-3322 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2017 |
| Cilt / Sayı / Sayfa | 87 / 0 / 561–567 | DOI | 10.1016/j.biopha.2017.01.003 |
| Makale Linki | http://dx.doi.org/10.1016/j.biopha.2017.01.003 | ||
| Özet |
| BackgroundPathogenesis of ischemic brain injury is occurred by crucial metabolic reasons. For instance, oxidative stress from free radical generation is causing to the thrombotic cerebrovascular stroke. In this case, the measurement of the oxidative stress is very important for a better understanding of the stroke pathophysiology. Because, the oxidative stress in stroke is generally assumed as one of the mechanisms taking part in neuronal damage. Thus, oxidative stress has a vital role in the cholinergic system.MethodsWe performed on 18 adult patients with stroke and 24 healthy persons as control subjects. First, acetylcholinesterase (AChE) activity and oxidative status were assayed in plasma and subsequently, quantitative gene expression of acetylcholinesterase was determined in leukocytes of patients diagnosed with acute stage of ischemia.ResultIt was observed an increase in levels of the protein carbonyl … |
| Anahtar Kelimeler |
| Gene expression | Ischemic stroke | Oxidative stress | Free radical | Acetylcholinesterase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 76 |
| Google Scholar | 104 |