Synthesis In Vitro Antimicrobial and Antioxidant Activities of Some New 4 5 Dihydro 1H 1 2 4 triazol 5 one Derivatives
Yazarlar (6)
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
Doç. Dr. Onur AKYILDIRIM Kafkas Üniversitesi, Türkiye
Mehmet Lütfi Yola Sinop Üniversitesi, Türkiye
Özlem Gürsoy Kol Kafkas Üniversitesi, Türkiye
Mustafa Çelebier Hacettepe Üniversitesi, Türkiye
Didem Kart
Hacettepe Üniversitesi, Türkiye
Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Archiv der Pharmazie | ||
| Dergi ISSN | 0365-6233 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SSCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2013 |
| Cilt / Sayı / Sayfa | 346 / 6 / 470–480 | DOI | 10.1002/ardp.201300048 |
| Makale Linki | http://doi.wiley.com/10.1002/ardp.201300048 | ||
| Özet |
| AbstractA series of compounds derived from 4,5‐dihydro‐1H‐1,2,4‐triazol‐5‐one were synthesized and characterized by spectral data. The 12 new compounds were analyzed for their potential in vitro antioxidant activities by three different methods. Compound 4f showed the best activity for the iron binding. In addition, the compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide in non‐aqueous solvents. The RP‐HPLC capacity factors (k′) of the series were also determined on a C18 column, with methanol/water as the mobile phase. The correlation between log k′ with the percentage of methanol in the mobile phase was used for the determination of the log kw values for these compounds. The antimicrobial activities of these compounds were also screened against bacteria and yeast. |
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BM Sürdürülebilir Kalkınma Amaçları
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