Efficacies of vitamin D and omega 3 polyunsaturated fatty acids on experimental endometriosis
Yazarlar (10)
Prof. Dr. Alpaslan Akyol Fırat Üniversitesi, Türkiye
Memet Şimşek
Adıyaman Üniversitesi, Türkiye
Adıyaman Üniversitesi, Türkiye
Raşit İlhan
Behzat Can
Dr. Öğr. Üyesi Melike Başpınar Fırat Üniversitesi, Türkiye
Hatice Akyol
Doç. Dr. Hüseyin Fatih GÜL Kafkas Üniversitesi, Türkiye
Prof. Dr. Mehmet Ferit Gürsu Fırat Üniversitesi, Türkiye
Prof. Dr. Salih Burçin Kavak Fırat Üniversitesi, Türkiye
Mehmet Mustafa Akın
Fırat Üniversitesi, Türkiye
Fırat Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (Q4) | ||
| Dergi ISSN | 1028-4559 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2016 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-12-2016 |
| Cilt / Sayı / Sayfa | 55 / 6 / 835–839 | DOI | 10.1016/j.tjog.2015.06.018 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1028455916301954 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| The aim of this study was to investigate the effects of 1,25-dihydroxyvitamin-D3 (vitamin D) and omega-3 polyunsaturated fatty acids (omega-3 PUFA) on experimentally induced endometriosis in a rat model. A prospective, single-blind, randomized, controlled experimental study was performed on 30 Wistar female rats. Endometriosis was surgically induced by implanting endometrial tissue on the abdominal peritoneum. Four weeks later, a second laparotomy was performed to assess pre-treatment implant volumes and cytokine levels. The rats were randomized into three groups: vitamin D group (42 μg/kg/day), omega-3 PUFA group (450 mg/kg/day), and control group (saline 0.1 mL/rat/day). These treatments were administered for 4 weeks. At the end of treatment, a third laparotomy was performed for the assessment of cytokine levels, implant volumes (post-treatment) and implants were totally excised for histopathologic examination. Pre- and post-treatment volumes, cytokine levels within the groups, as well as stromal and glandular tissues between the groups were compared. The mean post-treatment volume was statistically significantly reduced in the omega-3 PUFA group (p=0.02) and the level of the interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF) in the peritoneal fluid were significantly decreased at the end of treatment in the omega-3 PUFA group (p=0.02, p=0.03, and p=0.03, respectively). In the vitamin D group, only IL-6 levels were significantly decreased. In the histopathologic examination, the glandular tissue and stromal tissue scores of the implants were significant lower in the omega-3 PUFA group (p=0.03 and p=0.02). Omega-3 PUFA caused significant regression of endometriotic implants. Vitamin D has not been as effective as omega-3 PUFA on endometriosis. |
| Anahtar Kelimeler |
| endometriosis | omega-3 polyunsaturated fatty acid | rat | vitamin D |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 30 |