| Yazarlar |
Alpaslan Akyol
Fırat Üniversitesi, Türkiye |
|
Memet Şimşek
Adıyaman Üniversitesi, Türkiye |
|
Raşit İlhan
Türkiye |
|
Behzat Can
Türkiye |
|
Melike Başpınar
Fırat Üniversitesi, Türkiye |
|
Hatice Akyol
Türkiye |
Doç. Dr. Hüseyin Fatih GÜL
Kafkas Üniversitesi, Türkiye |
|
Mehmet Ferit Gürsu
Fırat Üniversitesi, Türkiye |
|
Salih Burçin Kavak
Fırat Üniversitesi, Türkiye |
|
Mehmet Mustafa Akın
Fırat Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to investigate the effects of 1,25-dihydroxyvitamin-D3 (vitamin D) and omega-3 polyunsaturated fatty acids (omega-3 PUFA) on experimentally induced endometriosis in a rat model. A prospective, single-blind, randomized, controlled experimental study was performed on 30 Wistar female rats. Endometriosis was surgically induced by implanting endometrial tissue on the abdominal peritoneum. Four weeks later, a second laparotomy was performed to assess pre-treatment implant volumes and cytokine levels. The rats were randomized into three groups: vitamin D group (42 μg/kg/day), omega-3 PUFA group (450 mg/kg/day), and control group (saline 0.1 mL/rat/day). These treatments were administered for 4 weeks. At the end of treatment, a third laparotomy was performed for the assessment of cytokine levels, implant volumes (post-treatment) and implants were totally excised for histopathologic examination. Pre- and post-treatment volumes, cytokine levels within the groups, as well as stromal and glandular tissues between the groups were compared. The mean post-treatment volume was statistically significantly reduced in the omega-3 PUFA group (p=0.02) and the level of the interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF) in the peritoneal fluid were significantly decreased at the end of treatment in the omega-3 PUFA group (p=0.02, p=0.03, and p=0.03, respectively). In the vitamin D group, only IL-6 levels were significantly decreased. In the histopathologic examination, the glandular tissue and stromal tissue scores of the implants were significant lower in the omega-3 PUFA group (p=0.03 and p=0.02). Omega-3 PUFA caused significant regression of endometriotic implants. Vitamin D has not been as effective as omega-3 PUFA on endometriosis. |
| Anahtar Kelimeler |
| endometriosis | omega-3 polyunsaturated fatty acid | rat | vitamin D |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY |
| Dergi ISSN | 1028-4559 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2016 |
| Cilt No | 55 |
| Sayı | 6 |
| Sayfalar | 835 / 839 |
| Doi Numarası | 10.1016/j.tjog.2015.06.018 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1028455916301954 |
| Atıf Sayıları | |
| WoS | 22 |
