The protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage in rats
Yazarlar (6)
Burcu Gül Baykalır
Türkiye
Sur Arslan Aslıhan
Türkiye
Seda İflazoğlu Mutlu
Türkiye
Pınar Tatlı Seven
Fırat Üniversitesi, Türkiye
Mine Yaman
Türkiye
Doç. Dr. Hüseyin Fatih GÜL
Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH (Q4) | ||
| Dergi ISSN | 0300-9831 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2021 |
| Cilt / Sayı / Sayfa | 91 / 5 / 427–438 | DOI | 10.1024/0300-9831/a000653 |
| Makale Linki | http://dx.doi.org/10.1024/0300-9831/a000653 | ||
| Özet |
| The aim of this study was to investigate the possible protective effects of chrysin on oxidative status and histological alterations against carbon tetrachloride (CCl)-induced liver and kidney tissue in rats. The animals were randomly divided into four groups; the control, chrysin (100 mg/kg), CCl (0.5 ml/kg) and chrysin + CCl groups. Liver and kidney injuries were assessed by biochemical and histopathological examinations. The levels of malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD) activity were measured in tissues. Serum tumor necrosis factor-α (TNF-α), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine levels were also measured in blood samples. MDA, serum TNF-α, AST, ALT, urea, and creatinine levels (p < 0.05) were significantly higher, and SOD activity and GSH level were significantly (p < 0.05) lower in the CCl group than in the control group. Treatment with chrysin in the chrysin + CCl group decreased MDA, AST, ALT, creatinine, and TNF-α levels (p < 0.05), and increased SOD activity, GSH levels (p < 0.05), and serum TNF-α levels (p < 0.05). In addition, body weight change (BWC) (p < 0.05) and feed intake (FI) were significantly lower (p < 0.001) in the CCl group than in the control group. Moreover, treatment with chrysin increased BWC and FI in the chrysin + CCl group compared with that in the CCl group. These findings also confirmed by histopathological examination. The chrysin treatment ameliorated the CCl-induced biochemical and pathological alterations. These results demonstrated that chrysin provided amelioration on the rat liver and kidney tissues CCl-induced injury by increasing the antioxidant activity. |
| Anahtar Kelimeler |
| Chrysin | carbon tetrachloride | antioxidant | kidney | liver |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 17 |