| Yazarlar |
Doç. Dr. Levent ŞAHİN
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Erdem TOKTAY
Türkiye |
Dr. Öğr. Üyesi Ahmet HARMANKAYA
Türkiye |
Doç. Dr. Pınar AKSU KILIÇLE
Türkiye |
Muhammed Yayla
Türkiye |
Doç. Dr. Hüseyin Fatih GÜL
Kafkas Üniversitesi, Türkiye |
| Özet |
| Purpose: We aimed to investigate dragon fruit (Hylocereus polyrhizus) extract effectiveness by creating a nephropathy model with contrast media toxicity after dehydration and furosemide administration to rats. Methods: Total 36 male Sprague dawley rats were randomly allocated into 6 groups (n: 6). At the end of the experiment kidney organs and blood was taken for histopathologic and biochemical analyze (malondialdehyde, glutathione, serum urea nitrogen and serum creatine). Results: Renal injury markers of serum urea nitrogen and creatinine levels decreased (p<0.05) in the groups that given dragon fruit extract depending on the dose manner compared to the group that was given contrast media. While oxidative stress increased in given contrast media group, MDA levels improved statistically significance in the groups given dragon fruit extract depending on the dose compared to the group that was given contrast media. Also tissue GSH levels increased in the groups given dragon fruit extract depending on the dose compared to the group that was given contrast media. Vacuolization damage was minimal and inflammation was not seen in these groups according to the histopathological analyses. Conclusion: Dragon fruit extract, a strong antioxidative agent, application together with contrast media can play a protective role against renal tubule via reduced renal injury markers, oxidative damage. |
| Anahtar Kelimeler |
| Contrast induced nephropathy | dragon fruit extract | kidney | oxidative stress | rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES |
| Dergi ISSN | 2458-8938 |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2021 |
| Cilt No | 5 |
| Sayı | 3 |
| Sayfalar | 117 / 125 |
| Doi Numarası | 10.30621/jbachs.943752 |
| Makale Linki | http://dx.doi.org/10.30621/jbachs.943752 |
| Atıf Sayıları |
