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Rationale, Design, and Methodology of the APOLLON trial: A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejectiON fraction   
Yazarlar
Bülent Özlek
Türkiye
Eda Özlek
Türkiye
Oğuzhan Çelik
Türkiye
Cem Çil
Türkiye
Volkan Doğan
Muğla Sıtkı Koçman Üniversitesi, Türkiye
Mehmet Tekinalp
Türkiye
Hicaz Zencirkıran Ağuş
Türkiye
Serkan Kahraman
İstanbul Rumeli Üniversitesi, Türkiye
Altuğ Ösken
Türkiye
Prof. Dr. İbrahim RENCÜZOĞULLARI Prof. Dr. İbrahim RENCÜZOĞULLARI
Kafkas Üniversitesi, Türkiye
Veysel Ozan Tanık
Türkiye
Lütfü Bekar
Hitit Üniversitesi, Türkiye
Mustafa Ozan Çakır
Zonguldak Bülent Ecevit Üniversitesi, Türkiye
Bedri Caner Kaya
Sağlık Bilimleri Üniversitesi, Türkiye
Hakan Tibilli
Türkiye
Yunus Çelik
Türkiye
Özcan Başaran
Türkiye
Kadir Uğur Mert
Eskişehir Osmangazi Üniversitesi, Türkiye
Samet Sevinç
Türkiye
Erkan Demirci
Türkiye
Engin Dondurmacı
Türkiye
Murat Biteker
Muğla Sıtkı Koçman Üniversitesi, Türkiye
Özet
Objective: Although almost half of chronic heart failure (HF) patients have mid-range (HFmrEF) and preserved left-ventricular ejection fraction(HFpEF), no studies have been carried out with these patients in our country. This study aims to determine the demographic characteristics andcurrent status of the clinical background of HFmrEF and HFpEF patients in a multicenter trial.Methods: A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejectiON fraction (APOLLON) trial will bean observational, multicenter, and noninterventional study conducted in Turkey. The study population will include 1065 patients from 12 sites inTurkey. All data will be collected at one point in time and the current clinical practice will be evaluated (ClinicalTrials.gov number NCT03026114).Results: We will enroll all consecutive patients admitted to the cardiology clinics who were at least 18 years of age and had New York HeartAssociation class II, III, or IV HF, elevated brain natriuretic peptide levels within the last 30 days, and an left ventricular ejection fraction (LVEF)of at least 40%. Patients fulfilling the exclusion criteria will not be included in the study. Patients will be stratified into two categories accordingto LVEF: mid-range EF (HFmrEF, LVEF 40%-49%) and preserved EF (HFpEF, LVEF ≥50%). Regional quota sampling will be performed to ensure thatthe sample was representative of the Turkish population. Demographic, lifestyle, medical, and therapeutic data will be collected by this specificsurvey.Conclusion: The APOLLON trial will be the largest and most comprehensive study in Turkey evaluating HF patients with a LVEF ≥40% and will alsobe the first study to specifically analyze the recently designated HFmrEF category.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı The Anatolian Journal of Cardiology
Dergi ISSN 2149-2263
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 01-2018
Cilt No 19
Sayfalar 311 / 318
Doi Numarası 10.14744/AnatolJCardiol.2018.95595
Makale Linki https://www.journalagent.com/anatoljcardiol/pdfs/AJC-95595-ORIGINAL_INVESTIGATION-OZLEK.pdf