HLA Alleles and haplotypes in the East Black Sea Turkish population
Yazarlar (7)
Prof. Dr. Fahri Uçar Akdeniz Üniversitesi, Türkiye
Ercüment Ovalı
Alper Pakdemir
Prof. Dr. İlhami GÖK Kafkas Üniversitesi, Türkiye
Sami Kartı
Ahmet Alver Karadeniz Teknik Üniversitesi, Türkiye
Ersan Kalay Karadeniz Teknik Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | TRANSPLANTATION PROCEEDINGS | ||
| Dergi ISSN | 0041-1345 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2004 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-11-2004 |
| Cilt / Sayı / Sayfa | 36 / 9 / 2610–2614 | DOI | 10.1016/j.transproceed.2004.10.020 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0041134504011868 | ||
| UAK Araştırma Alanları |
Temel İmmünoloji
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| Özet |
| HLA class I and class II alleles were studied for the first time in 234 unrelated individuals inhabiting the East Black Sea region in Turkey. This region is on the historic silk road and close to Georgia. HLA class I (A* and B*) and class II DRB1* typing was done by the PCR-SSP method. A total of 17 HLA-A* alleles, 34 HLA-B* alleles, and 15 HLA-DRB1* alleles were detected. HLA-A*-B*, A*-DRB1*, and B*-DRB1* two-loci linkage disequilibrium data show that two specific combinations (A2-B35, A2-DRB1*11, and B35-DRB1*13) had the highest frequency (more than three or four times) compared with the other two-loci combinations, possibly reflecting an ancient founder effect. A*24 B*18 DRB1*13 and A*32 B*27 DRB1*11 were the most common haplotypes in the east Black sea Turkish population. HLA-B* showed the highest heterozygosity (94%) among the samples. The observed diversity in the HLA-A* and HLA … |
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| Web of Science | 2 |
| Google Scholar | 5 |