Polymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey
Yazarlar (5)
Prof. Dr. İlhami GÖK Kafkas Üniversitesi, Türkiye
Meryem Baday
Kemal Kılıç
Süleyman Cetinkünar
Bülent Çağlar Bilgin
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (Q4) | ||
| Dergi ISSN | 1512-8601 Dergi Bilgileri (2014) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2014 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 13-09-2014 |
| Cilt / Sayı / Sayfa | 14 / 4 / 214–218 | DOI | 10.17305/bjbms.2014.4.7 |
| Makale Linki | http://www.bjbms.org/ | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| We studied the prevalence of polymorphisms in genes XRCC2 and XRCC3 in stomach cancer patients who lived in North Eastern Turkey. A total of 61 cancer patients and 78 controls were included in this study. Single nucleotide changes were studied in XRCC2 and XRCC3 genes at locus Arg188His and Thr241Met. Blood samples were taken from the patients and controls, and DNA was isolated. The regions of interest were amplified using a polymerase chain reaction method. After amplification, we used restriction enzymes (HphI and NcoI) to digest the amplified product. Digested product was then run through gel electrophoresis. We identified changes in the nucleotides in these specific regions. It was found that the Arg188His polymorphism of the XRCC2 gene was about 39% (24 out of the 61) among cancer patients. However, only 15% (12 out of 78) of the control group indicated this polymorphism. We also … |
| Anahtar Kelimeler |
| gastric cancer | XRCC2 and XRCC3 genes | polymorphism | Turkey |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Google Scholar | 21 |