CARD15 Gene 3020insC Mutation with Inflammatory Bowel Diseases Patients in the Black Sea Region of Turkey
Yazarlar (6)
Gök İlhami
Ucar Fahri
Ozgur Orhan
Celebi Altay
Sentürk Omer
Hulagusadettin
| Makale Türü | Özgün Makale (Diğer hakemli uluslarası dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Macedonian Journal of Medical Sciences | ||
| Dergi Tarandığı Indeksler | EBSCO | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2014 |
| Cilt / Sayı / Sayfa | 7 / 2 / 215–218 | DOI | 10.3889/MJMS.1857-5773.2014.0406 |
| Makale Linki | http://www.mjms.mk/ | ||
| Özet |
| BACKGROUND: The role of the CARD15 gene 3020insC frameshift mutation in the pathogenesis of inflammatory bowel diseases (IBD) investigated without a definitive conclusion. The incidence of this mutation in Turkish patients with Crohn’ s disease is not known.OBJECTIVE: We investigated whether the CARD15/NOD2 3020insC frameshift mutation is a risk factor for patients with inflammatory bowel disease in Black Sea Region population in Turkey.METHODS: We studied 3020insC mutation of CARD15/NOD2 gene by allele-specific multiplex PCR in 69 patients with IBD (18 Crohn’ s disease [CD] and 51 ulcerative colitis [UC]) and 101 ethnically matched healthy controls.RESULTS: CARD15/NOD2 3020insC frameshift mutation was positive in 7/18 (38.8%), 13/51 (25.5%), and 4/101 (4%) of CD, UC, and healthy control groups, respectively. None of the controls or patients with Crohn’ s disease and ulcerative colitis was homozygous for this mutations.CONCLUSION: This study is to investigate a relation between CARD15/NOD2 3020insC frameshift mutation and in patients with IBD in the Turkish Population. C-insertion frameshift mutation is a major contributor to the susceptibility to both CD and UC, but it is not specific to patients with CD in Turkish population. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 3 |