| Yazarlar |
Osman Nuri Keleş
Atatürk Üniversitesi, Türkiye |
Prof. Dr. Serpil CAN
Kafkas Üniversitesi, Türkiye |
|
Gülşen Çığşar
Kafkas Üniversitesi, Türkiye |
|
Suat Çolak
Erzincan Üniversitesi, Türkiye |
|
Hüseyin Serkan Erol
Atatürk Üniversitesi, Türkiye |
|
Nurhan Akaras
Atatürk Üniversitesi, Türkiye |
|
Burak Erdemci
Atatürk Üniversitesi, Türkiye |
|
Bülent Çağlar Bilgin
Türkiye |
Doç. Dr. İsmail CAN
Kafkas Üniversitesi, Türkiye |
|
Bünyami Ünal
Atatürk Üniversitesi, Türkiye |
|
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to evaluate the efects of β -1,3-(D)-glucan as an antioxidant and tissue protective agent and studythe biochemical, histopathologic, and immunohistochemical efects of first therapeutic proteasome inhibitor bortezomib on theliver for treating relapsed multiple myeloma. The experiment included 36 adult male rats, which were divided into four treatmentgroups: control (healthy); bortezomib-treated; β-1,3-D-glucan-treated; and bortezomib + β-1,3-(D)-glucan-treated. Each group wassubdivided into two subgroups based on time of sacrifice (48 or 72 h). After the experiments, superoxide dismutase (SOD) activityand lipid peroxidation (LPO) amounts were determined, and immunohistochemical and histopathological changes were examinedin all rat liver tissues. β -1,3-(D)-Glucan treatment normalized changes of LPO and stimulated an over activity of endogenous SOD.The results of the histopathologic parameters showed that treatment with β -1,3-(D)-Glucan in the bortezomib group amelioratedthe development of non-specific reactive hepatitis (NSRH) and Kupfer cell activation via NF-kB. Administration of β -1,3-(D)-Glucan isefective in reversing tissue damage induced by bortezomib in rat livers. |
| Anahtar Kelimeler |
| Bortezomib,beta-1,3-(D)-glucan,Oxidative stress,Liver,Histology |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Kafkas Universitesi Veteriner Fakultesi Dergisi |
| Dergi ISSN | 1300-6045 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2014 |
| Cilt No | 20 |
| Sayfalar | 929 / 938 |
| Doi Numarası | 10.9775/kvfd.2014.11413 |
| Makale Linki | http://vetdergi.kafkas.edu.tr/extdocs/2014_6/929-938.pdf |
| Atıf Sayıları | |
| WoS | 6 |
| TRDizin | 2 |
