Hepatoprotective Effects of B-1,3-(D)-Glucan on Bortezomib-Induced Liver Damage in Rats
Yazarlar (11)
Osman Nuri Keleş
Atatürk Üniversitesi, Türkiye
Prof. Dr. Serpil CAN
Kafkas Üniversitesi, Türkiye
Gülşen Çığşar
Kafkas Üniversitesi, Türkiye
Suat Çolak
Erzincan Üniversitesi, Türkiye
Hüseyin Serkan Erol
Atatürk Üniversitesi, Türkiye
Nurhan Akaras
Atatürk Üniversitesi, Türkiye
Burak Erdemci
Atatürk Üniversitesi, Türkiye
Bülent Çağlar Bilgin
Kafkas Üniversitesi, Türkiye
Doç. Dr. İsmail CAN
Kafkas Üniversitesi, Türkiye
Bünyami Ünal
Atatürk Üniversitesi, Türkiye
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Kafkas Üniversitesi Veteriner Fakültesi Dergisi | ||
| Dergi ISSN | 1300-6045 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2014 |
| Cilt / Sayı / Sayfa | 20 / 6 / 929–938 | DOI | 10.9775/kvfd.2014.11413 |
| Makale Linki | http://vetdergi.kafkas.edu.tr/extdocs/2014_6/929-938.pdf | ||
| Özet |
| The aim of this study was to evaluate the efects of β -1,3-(D)-glucan as an antioxidant and tissue protective agent and studythe biochemical, histopathologic, and immunohistochemical efects of first therapeutic proteasome inhibitor bortezomib on theliver for treating relapsed multiple myeloma. The experiment included 36 adult male rats, which were divided into four treatmentgroups: control (healthy); bortezomib-treated; β-1,3-D-glucan-treated; and bortezomib + β-1,3-(D)-glucan-treated. Each group wassubdivided into two subgroups based on time of sacrifice (48 or 72 h). After the experiments, superoxide dismutase (SOD) activityand lipid peroxidation (LPO) amounts were determined, and immunohistochemical and histopathological changes were examinedin all rat liver tissues. β -1,3-(D)-Glucan treatment normalized changes of LPO and stimulated an over activity of endogenous SOD.The results of the histopathologic parameters showed that treatment with β -1,3-(D)-Glucan in the bortezomib group amelioratedthe development of non-specific reactive hepatitis (NSRH) and Kupfer cell activation via NF-kB. Administration of β -1,3-(D)-Glucan isefective in reversing tissue damage induced by bortezomib in rat livers. |
| Anahtar Kelimeler |
| Bortezomib | beta-1,3-(D)-glucan | Oxidative stress | Liver | Histology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 13 |
| TRDizin | 9 |