| Yazarlar |
Turan Karaca
Trakya Üniversitesi, Türkiye |
|
Nejdet Şimşek
Balıkesir Üniversitesi, Türkiye |
|
Serap Uslu
İstanbul Medeniyet Üniversitesi, Türkiye |
|
Yıldıray Kalkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
Doç. Dr. İsmail CAN
Kafkas Üniversitesi, Türkiye |
|
Adem Kara
Atatürk Üniversitesi, Türkiye |
|
Mecit Yörük
Yüzüncü Yıl Üniversitesi, Türkiye |
| Özet |
| Traditional medicines and health supplements have historically been used to treat many illnesses but most of them have not been evaluated objectively to prove their efficacy. We have been investigating the effects of royal jelly (RJ) supplements on acetic acid-induced colitis on the distribution of CD3(+), CD5(+), CD45(+) T-cell and CD68(+) cells in rats. The rats were divided into four equal groups: control group, royal jelly-treated (RJ - 150mgkg(-1) body weight), acetic acid-treated (colitis) and acetic acid-treated (colitis)+royal jelly (CRJ - 150mgkg(-1) body weight). Colitis was induced by intracolonic instillation of 4% acetic acid; the control group received physiological saline (10mLkg(-1)). Colon samples were obtained under deep anaesthesia from animals in four groups. Tissues were fixed in 10% formalin neutral buffer solution for 24h and embedded in paraffin. The proliferative response of CD3(+) and CD45(+) T cells stimulated with colitis was affected by colitis treated with RJ. No differences were found in CD5(+) T cells and CD68(+) macrophages in the colitis treated with RJ. This study has shown that RJ has anti-inflammatory and cell regeneration effect in the colon of rats with acetic acid induced colitis. |
| Anahtar Kelimeler |
| Colitis | Royal jelly | Lymphocytes | Macrophages | Rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ALLERGOLOGIA ET IMMUNOPATHOLOGIA |
| Dergi ISSN | 0301-0546 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2012 |
| Cilt No | 40 |
| Sayı | 6 |
| Sayfalar | 357 / 361 |
| Doi Numarası | 10.1016/j.aller.2011.09.004 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0301054611003259 |
| Atıf Sayıları | |
| WoS | 24 |
