Prognostic Values of Lesion Volume and Biochemıcal Markers in Ischemic and Hemorrhagic Stroke: a Stereologıcal and Clinical Study
Yazarlar (11)
Asuman Orhan Varoğlu
İstanbul Medeniyet Üniversitesi, Türkiye
Mutlu Kuyucu
Türkiye
Recep Demir
Atatürk Üniversitesi, Türkiye
Hamit Acemoğlu
Atatürk Üniversitesi, Türkiye
Fatih Akçay
Atatürk Üniversitesi, Türkiye
Öznur Gürpınar
Türkiye
Fazıl Alper Tekeli
Türkiye
Güllü İştar Dolapçı
Türkiye
Didem Kart
Türkiye
Elmas Ebrü Yalçın
Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | INTERNATIONAL JOURNAL OF NEUROSCIENCE | ||
| Dergi ISSN | 0020-7454 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2009 |
| Cilt / Sayı / Sayfa | 119 / 12 / 2206–2218 | DOI | 10.3109/00207450903222733 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/00207450903222733 | ||
| Özet |
| Our aim was to evaluate the relationship between lesion volume, serum level of biochemical markers, and clinical situation in ischemic and hemorrhagic stroke. MRI was obtained on 33 ischemic and 28 hemorrhagic strokes. The Cavalieri method was used to measure the volume. To evaluate neurological situation of the patients, we used the National Institutes of Health Stroke Scale (NIHSS) and Rankin Disability Scores at the first, third, seventh, and thirtieth days. We measured the level of leptin, high sensitivity C-reactive protein (hs-CRP), insulin, cortisol, fibrinogen, protein C, protein S, von Willebrand factor, D-dimer, Antitrombin III, and Factor VIII (F VIII) at the same time intervals. In ischemic events, cortisol level at third and seventh days, and fibrinogen level at the first day were correlated with lesion volumes (r = 0.5, p = .02; r = 0.4, p = .02; r = 0.5, p = .005, respectively). In hemorrhagic events, only fibrinogen level was correlated with lesion volumes at third day (r = 0.6, p = .04). No significant differences were found among all these biochemical parameters, neurological situation (p > .05), and lesion volumes at all times. In the prediction of stroke prognosis, lesion volume and all of the evaluated biochemical parameters are not deterministic factors. |
| Anahtar Kelimeler |
| biochemical markers | Cavalieri method | cerebral hemorrhage | cerebral infarct | lesion volume | prognosis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 9 |