Nigella sativa reduces tissue damage in rat ovaries subjected to torsion and detorsion: oxidative stress, proinflammatory response and histopathological evaluation
Yazarlar (9)
Yasin Bayır
Atatürk Üniversitesi, Türkiye
Yalçın Karagöz
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Emre Karakuş
Atatürk Üniversitesi, Türkiye
Abdulmecit Albayrak
Atatürk Üniversitesi, Türkiye
Özlem Şengül
Yıldırım Beyazıt Üniversitesi, Türkiye
Nuh Yayla
Türkiye
Ufuk Kuşkun
Türkiye
Mevlüt Sait Keleş
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | GYNECOLOGIC AND OBSTETRIC INVESTIGATION | ||
| Dergi ISSN | 0378-7346 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | 74 / 1 / 41–49 | DOI | 10.1159/000336295 |
| Makale Linki | https://www.karger.com/Article/FullText/336295 | ||
| Özet |
| To evaluate biochemically and histopathologically the effects of Nigella sativa (NS) in experimental ischemia and ischemia/reperfusion (I/R) injury in rat ovaries. Thirty-six female rats were divided into 6 groups: group I = sham operation; group II = 500 mg/kg NS + sham operation; group III = bilateral ovarian ischemia; group IV = 500 mg/kg NS + ischemia; group V = 3-hour period of ischemia + 3-hour reperfusion, and group VI: 3-hour period of ischemia + 500 mg/kg NS 2.5 h after the induction of ischemia + 3-hour reperfusion. At the end of ischemia, the bilateral vascular clips were removed, and 3-hour reperfusion was continued. IL-1β, IL-6, and TNF-α cytokine levels in serum, and superoxide dismutase (SOD), myeloperoxidase (MPO), glutathione (GSH), and malondialdehyde (MDA) levels were determined. I/R increased the MDA level and MPO activity while significantly decreasing the SOD activity and GSH level when compared to the sham. The 500-mg/kg dose of NS before I/R reversed the trend in MDA levels, MPO activity, SOD activity, and GSH levels. Ischemia and I/R increased the serum levels of IL-1β, IL-6, and TNF-α, while the administration of NS decreased the serum levels of these cytokines. The administration of NS is effective in reversing tissue damage induced by ischemia and/or I/R in ovaries. |
| Anahtar Kelimeler |
| Nigella sativa | Ischemia | Ovary | Oxidative stress | Rat | Interleukins | Malondialdehyde | Myeloperoxidase | Glutathione | Superoxide dismutase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 34 |