| Yazarlar |
Yasin Bayır
Atatürk Üniversitesi, Türkiye |
|
Yalçın Karagöz
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Emre Karakuş
Atatürk Üniversitesi, Türkiye |
|
Abdulmecit Albayrak
Atatürk Üniversitesi, Türkiye |
|
Özlem Şengül
Yıldırım Beyazıt Üniversitesi, Türkiye |
Doç. Dr. İsmail CAN
Kafkas Üniversitesi, Türkiye |
|
Nuh Yayla
Türkiye |
|
Ufuk Kuşkun
Türkiye |
|
Mevlüt Sait Keleş
Atatürk Üniversitesi, Türkiye |
| Özet |
| To evaluate biochemically and histopathologically the effects of Nigella sativa (NS) in experimental ischemia and ischemia/reperfusion (I/R) injury in rat ovaries. Thirty-six female rats were divided into 6 groups: group I = sham operation; group II = 500 mg/kg NS + sham operation; group III = bilateral ovarian ischemia; group IV = 500 mg/kg NS + ischemia; group V = 3-hour period of ischemia + 3-hour reperfusion, and group VI: 3-hour period of ischemia + 500 mg/kg NS 2.5 h after the induction of ischemia + 3-hour reperfusion. At the end of ischemia, the bilateral vascular clips were removed, and 3-hour reperfusion was continued. IL-1β, IL-6, and TNF-α cytokine levels in serum, and superoxide dismutase (SOD), myeloperoxidase (MPO), glutathione (GSH), and malondialdehyde (MDA) levels were determined. I/R increased the MDA level and MPO activity while significantly decreasing the SOD activity and GSH level when compared to the sham. The 500-mg/kg dose of NS before I/R reversed the trend in MDA levels, MPO activity, SOD activity, and GSH levels. Ischemia and I/R increased the serum levels of IL-1β, IL-6, and TNF-α, while the administration of NS decreased the serum levels of these cytokines. The administration of NS is effective in reversing tissue damage induced by ischemia and/or I/R in ovaries. |
| Anahtar Kelimeler |
| Nigella sativa | Ischemia | Ovary | Oxidative stress | Rat | Interleukins | Malondialdehyde | Myeloperoxidase | Glutathione | Superoxide dismutase |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | GYNECOLOGIC AND OBSTETRIC INVESTIGATION |
| Dergi ISSN | 0378-7346 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2012 |
| Cilt No | 74 |
| Sayı | 1 |
| Sayfalar | 41 / 49 |
| Doi Numarası | 10.1159/000336295 |
| Makale Linki | https://www.karger.com/Article/FullText/336295 |
| Atıf Sayıları | |
| WoS | 34 |
