Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4)
Yazarlar (8)
Emre Karakuş
Atatürk Üniversitesi, Türkiye
Ali Karadeniz
Balıkesir Üniversitesi, Türkiye
Nejdet Şimşek
Balıkesir Üniversitesi, Türkiye
Adem Kara
Atatürk Üniversitesi, Türkiye
Serap Yıldırım
Atatürk Üniversitesi, Türkiye
Yıldıray Kalkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Fikrullah Kısa
Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF HAZARDOUS MATERIALS | ||
| Dergi ISSN | 0304-3894 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2011 |
| Cilt / Sayı / Sayfa | 195 / 0 / 208–213 | DOI | 10.1016/j.jhazmat.2011.08.027 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0304389411010326 | ||
| Özet |
| The purpose of this study was to investigate possible beneficial effects of Panax ginseng (PG) on carbon tetrachloride (CCl(4))-induced acute hepatotoxicity in rats. CCl(4) challenge elevated serum enzyme activities of liver and some biochemical parameters, but these effects were prevented by the pretreatment of rats with PG. Histologically, a great amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver of CCl(4) group. Also, CD68(+) and caspase-3 staining cells were diffused in both lobular and portal areas. However, PG pretreatment had a little influence on the number of caspase-3 immunopositive staining cells in the liver, but CD68(+) staining areas were significantly decreased in the PG+CCl(4) when compared to CCl(4) group. We conclude that PG treatment may play a protective role by enhancing liver enzyme activities and recovering biochemical parameters, and improving the changes in histological structure against CCl(4)-induced liver damages in rats. |
| Anahtar Kelimeler |
| Panax ginseng | Carbon tetrachloride | Liver | Biochemistry | CD68(+) | Caspase-3 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 75 |