| Yazarlar |
Emre Karakuş
Atatürk Üniversitesi, Türkiye |
|
Ali Karadeniz
Balıkesir Üniversitesi, Türkiye |
|
Nejdet Şimşek
Balıkesir Üniversitesi, Türkiye |
Doç. Dr. İsmail CAN
Kafkas Üniversitesi, Türkiye |
|
Adem Kara
Atatürk Üniversitesi, Türkiye |
|
Serap Yıldırım
Atatürk Üniversitesi, Türkiye |
|
Yıldıray Kalkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Fikrullah Kısa
Türkiye |
| Özet |
| The purpose of this study was to investigate possible beneficial effects of Panax ginseng (PG) on carbon tetrachloride (CCl(4))-induced acute hepatotoxicity in rats. CCl(4) challenge elevated serum enzyme activities of liver and some biochemical parameters, but these effects were prevented by the pretreatment of rats with PG. Histologically, a great amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver of CCl(4) group. Also, CD68(+) and caspase-3 staining cells were diffused in both lobular and portal areas. However, PG pretreatment had a little influence on the number of caspase-3 immunopositive staining cells in the liver, but CD68(+) staining areas were significantly decreased in the PG+CCl(4) when compared to CCl(4) group. We conclude that PG treatment may play a protective role by enhancing liver enzyme activities and recovering biochemical parameters, and improving the changes in histological structure against CCl(4)-induced liver damages in rats. |
| Anahtar Kelimeler |
| Panax ginseng | Carbon tetrachloride | Liver | Biochemistry | CD68(+) | Caspase-3 |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF HAZARDOUS MATERIALS |
| Dergi ISSN | 0304-3894 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2011 |
| Cilt No | 195 |
| Sayfalar | 208 / 213 |
| Doi Numarası | 10.1016/j.jhazmat.2011.08.027 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0304389411010326 |
| Atıf Sayıları | |
| WoS | 72 |
