| Yazarlar (6) |
Cebrail Gürsul
Erzincan Üniversitesi, Türkiye |
|
Fazile Nur Ekinci Akdemir
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Hurrem Turan Akkoyun
Siirt Üniversitesi, Türkiye |
Doç. Dr. İsmail CAN
Kafkas Üniversitesi, Türkiye |
|
Mustafa Gül
Atatürk Üniversitesi, Türkiye |
|
İlhami Gülçin
Atatürk Üniversitesi, Türkiye |
| Özet |
| This study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p < 0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p < 0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p < 0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application. |
| Anahtar Kelimeler |
| Antioxidant enzymes | ischemia/reperfusion injury | Naringin | reactive oxygen species | skeletal muscle |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Dergi ISSN | 1475-6366 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2016 |
| Cilt No | 31 |
| Sayfalar | 56 / 61 |
| Doi Numarası | 10.3109/14756366.2016.1167050 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.3109/14756366.2016.1167050 |
| Atıf Sayıları | |
| WoS | 23 |
