Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats
Yazarlar (6)
Cebrail Gürsul
Erzincan Üniversitesi, Türkiye
Fazile Nur Ekinci Akdemir
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Hurrem Turan Akkoyun
Siirt Üniversitesi, Türkiye
Doç. Dr. İsmail CAN
Kafkas Üniversitesi, Türkiye
Mustafa Gül
Atatürk Üniversitesi, Türkiye
İlhami Gülçin
Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | ||
| Dergi ISSN | 1475-6366 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2016 |
| Cilt / Sayı / Sayfa | 31 / 0 / 56–61 | DOI | 10.3109/14756366.2016.1167050 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.3109/14756366.2016.1167050 | ||
| Özet |
| This study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p < 0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p < 0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p < 0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application. |
| Anahtar Kelimeler |
| Antioxidant enzymes | ischemia/reperfusion injury | Naringin | reactive oxygen species | skeletal muscle |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 27 |