Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats
Yazarlar (6)
Doç. Dr. Cebrail Gürsul Erzincan Üniversitesi, Türkiye
Doç. Dr. Fazile Nur Ekinci Akdemir Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Prof. Dr. Hurrem Turan Akkoyun Siirt Üniversitesi, Türkiye
Doç. Dr. İsmail CAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Mustafa Gül Atatürk Üniversitesi, Türkiye
Prof. Dr. İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Q1) | ||
| Dergi ISSN | 1475-6366 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2016 |
| Kabul Tarihi | 09-03-2016 | Yayınlanma Tarihi | 07-04-2016 |
| Cilt / Sayı / Sayfa | 31 / 0 / 56–61 | DOI | 10.3109/14756366.2016.1167050 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.3109/14756366.2016.1167050 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| This study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p < 0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p < 0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p < 0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application. |
| Anahtar Kelimeler |
| Antioxidant enzymes | ischemia/reperfusion injury | Naringin | reactive oxygen species | skeletal muscle |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 27 |