| Yazarlar (6) |
Doç. Dr. İsmail GÜLER
Ankara Medipol Üniversitesi, Türkiye |
İhsan Kuzucu
Türkiye |
|
Deniz Baklacı
Türkiye |
|
Rauf Oguzhan Kum
Türkiye |
|
Esra Özhamam
Türkiye |
|
Müge Özcan
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to assess whether nivolumab is ototoxic in rats and whether this ototoxicity is dose-dependent. Twelve rats were divided into two groups: Group 1 (control group, 6 rats, 12 ears) received intraperitoneal saline for 14 days. Group 2 (study group, 6 rats, 12 ears) and received two doses of 3 mg/kg intraperitoneal nivolumab within 14 days. Auditory brainstem responses (ABRs) were performed preoperatively and 4 and 8 weeks postoperatively. We compared between the groups, morphologic appearance of spiral ganglion cells and organ of Corti and density of spiral ganglion cells (measured with conventional light microscope connected to a personal computer). In our control group, both spiral ganglion and organ of corti had a normal morphological appearance. In our study group, spiral ganglion cells had a normal morphological appearance. However, some sections showed possibly mild degenerative changes in the organ of corti. Of 12 samples in the study group, four had a significant loss of density of spiral ganglion cells compared to the control group. The baseline ABR thresholds did not significantly differ between the groups (p=0.713). There was no statistically significant difference between the groups regarding ABR thresholds at week 4 (p=0.347). However, a statistically significant difference was observed in the ABR thresholds at week 8 (p=0.045). The results of our study showed that nivolumab treatment has ototoxic effects. Based on our results, we recommend monitoring the changes in the hearing ability of chemotherapy patients. |
| Anahtar Kelimeler |
| Ototoxicity | nivolumab | immunotherapy | animal study |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of International Advanced Otology |
| Dergi ISSN | 1308-7649 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2020 |
| Cilt No | 16 |
| Sayı | 2 |
| Sayfalar | 218 / 221 |
| Doi Numarası | 10.5152/iao.2020.7123 |
| Makale Linki | https://advancedotology.org/en/evaluation-of-nivolumab-for-ototoxic-effects-an-animal-study-in-rats-131523 |
| Atıf Sayıları | |
| WoS | 2 |
