Protective Effect of Hydrogen-Rich Saline on Spinal Cord Damage in Rats
Yazarlar (7)
Murat Kayabaş
Türkiye
Türkiye
Doç. Dr. Levent ŞAHİN Kafkas Üniversitesi, Türkiye
Doç. Dr. Mustafa MAKAV Kafkas Üniversitesi, Türkiye
Durıed Alwazeer
Türkiye
Türkiye
Levent Aras
Türkiye
Türkiye
Dr. Öğr. Üyesi Serdar YİĞİT Kafkas Üniversitesi, Türkiye
Tyler W. Lebaron Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Pharmaceuticals (Q1) | ||
| Dergi ISSN | 1424-8247 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2023 |
| Cilt / Sayı / Sayfa | 16 / 4 / – | DOI | 10.3390/ph16040527 |
| Makale Linki | https://www.mdpi.com/1424-8247/16/4/527/pdf?version=1680487751 | ||
| Özet |
| The anti-inflammatory and anti-apoptotic effects of molecular hydrogen, delivered as hydrogen-rich saline (HRS), on spinal cord injury was investigated. Four-month-old male Sprague Dawley rats (n = 24) were classified into four groups: (1) control—laminectomy only at T7-T10; (2) spinal injury—dura left intact, Tator and Rivlin clip compression model applied to the spinal cord for 1 min, no treatment given; (3) HRS group—applied intraperitoneally (i.p.) for seven days; and (4) spinal injury—HRS administered i.p. for seven days after laminectomy at T7–T10 level, leaving the dura intact and applying the Tator and Rivlin clip compression model to the spinal cord for 1 min. Levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) were measured in blood taken at day seven from all groups, and hematoxylin–eosin (H & E) and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) were used to stain the tissue samples. IL-6 and TNF-α levels were significantly lower in the group treated with HRS following the spinal cord injury compared to the group whose spinal cord was damaged. A decrease in apoptosis was also observed. The anti-inflammatory and anti-apoptotic effect of IL-6 may be a clinically useful adjuvant therapy after spinal cord injury. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |