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A New Agent in Prevention of Contrast-Induced Nephropathy: Dragon Fruit (Hylocereus polyrhizus) Extract    
Yazarlar
Doç. Dr. Levent ŞAHİN Doç. Dr. Levent ŞAHİN
Kafkas Üniversitesi, Türkiye
Doç. Dr. Erdem TOKTAY Doç. Dr. Erdem TOKTAY
Türkiye
Dr. Öğr. Üyesi Ahmet HARMANKAYA Dr. Öğr. Üyesi Ahmet HARMANKAYA
Türkiye
Doç. Dr. Pınar AKSU KILIÇLE Doç. Dr. Pınar AKSU KILIÇLE
Türkiye
Muhammed Yayla
Türkiye
Doç. Dr. Hüseyin Fatih GÜL Doç. Dr. Hüseyin Fatih GÜL
Kafkas Üniversitesi, Türkiye
Özet
Purpose: We aimed to investigate dragon fruit (Hylocereus polyrhizus) extract effectiveness by creating a nephropathy model with contrast media toxicity after dehydration and furosemide administration to rats. Methods: Total 36 male Sprague dawley rats were randomly allocated into 6 groups (n: 6). At the end of the experiment kidney organs and blood was taken for histopathologic and biochemical analyze (malondialdehyde, glutathione, serum urea nitrogen and serum creatine). Results: Renal injury markers of serum urea nitrogen and creatinine levels decreased (p<0.05) in the groups that given dragon fruit extract depending on the dose manner compared to the group that was given contrast media. While oxidative stress increased in given contrast media group, MDA levels improved statistically significance in the groups given dragon fruit extract depending on the dose compared to the group that was given contrast media. Also tissue GSH levels increased in the groups given dragon fruit extract depending on the dose compared to the group that was given contrast media. Vacuolization damage was minimal and inflammation was not seen in these groups according to the histopathological analyses. Conclusion: Dragon fruit extract, a strong antioxidative agent, application together with contrast media can play a protective role against renal tubule via reduced renal injury markers, oxidative damage.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı Journal of Basic and Clinical Health Sciences
Dergi ISSN 2458-8938
Dergi Tarandığı Indeksler ESCI
Makale Dili İngilizce
Basım Tarihi 09-2021
Cilt No 5
Sayı 3
Sayfalar 117 / 125
Doi Numarası 10.30621/jbachs.943752
Makale Linki http://dx.doi.org/10.30621/jbachs.943752