The Possible Protective effect of L carnitine on Tilmicosin induced Cardiotoxicity in Mice
Yazarlar (4)
Asım Kart Mehmet Akif Ersoy Üniversitesi, Türkiye
Kürşad Yapar Giresun Üniversitesi, Türkiye
Prof. Dr. Mahmut KARAPEHLİVAN Kafkas Üniversitesi, Türkiye
Mehmet Çitil Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Veterinary Medicine Series A | ||
| Dergi ISSN | 0931-184X | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2007 |
| Cilt / Sayı / Sayfa | 54 / 3 / 144–146 | DOI | 10.1111/j.1439-0442.2007.00897.x |
| Makale Linki | http://doi.wiley.com/10.1111/j.1439-0442.2007.00897.x | ||
| Özet |
| SummaryThe protective effect of l‐carnitine was investigated against tilmicosin‐induced cardiotoxic effects including blood creatine kinase (CK), CK‐MB, total sialic acid as well as the alterations in glutathione and malondialdehyde concentrations in mice. Thirty‐two Balb/C mice were divided into four groups including group 1 (control), group 2 (l‐carnitine, s.c., 500 mg/kg for 5 days), group 3 (tilmicosin, s.c., single dose of 75 mg/kg) and group 4 (l‐carnitine plus tilmicosin). Serum CK, CK‐MB and malondialdehyde (MDA) levels were significantly (P < 0.05) higher in group 3 compared with those of other groups. Total sialic acid level in group 3 was found to be significantly (P < 0.05) higher than that in groups 1 and 2, as well. Contrary to these results, glutathione level in group 3 was found to be significantly (P < 0.05) lower than that in groups 1 and 2. In group 4, serum CK, CK‐MB, MDA and total sialic acid levels were found to be significantly (P < 0.05) lower than those in group 3. These results suggest that tilmicosin is cardiotoxic in mice as evidenced by higher total sialic acid, CK and CK‐MB. In addition, tilmicosin caused the decrease in glutathione and increase in MDA levels. However, administration of l‐carnitine could ameliorate these adverse toxic effects of tilmicosin in mice. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |