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Protective effect of astaxanthin on experimental ovarian damage in rats     
Yazarlar
Dr. Öğr. Üyesi Abdulsamed KÜKÜRT Dr. Öğr. Üyesi Abdulsamed KÜKÜRT
Kafkas Üniversitesi, Türkiye
Prof. Dr. Mahmut KARAPEHLİVAN Prof. Dr. Mahmut KARAPEHLİVAN
Kafkas Üniversitesi, Türkiye
Özet
This study aimed to investigate the protective effect of astaxanthin (AS) on 3-nitropropionic acid (3-NPA) induced experimental ovarian damage in rats. Thirty two female Wistar rats were divided into four equal groups of eight each: control group (C); phosphate-buffered saline, AS group; AS (80 mg/kg) for 14 days, 3-NPA group; 3-NPA (6.25 mg/kg) twice a day for 7 days, 3-NPA + AS group; administered AS (80 mg/kg) for 14 days and 3-NPA (6.25 mg/kg) for 7 days. All injections were administered intraperitoneally. Rats were fed ad libitum with standard rat chow and tap water. Plasma and ovarian tissue total antioxidant capacity (TAC), total oxidant capacity (TOC) and oxidative stress index (OSI) levels, whole blood reduced glutathione (GSH), plasma paraoxonase 1 (PON1) activity, lipid profile, malondialdehyde (MDA), nitric oxide (NO), total sialic acid (TSA) and total thiol (TT) concentrations were analysed spectrophotometrically. Also, ovarian tissue histopathology was performed. We observed 3-NPA-induced histopathological ovarian damage significantly decreased the TAC (p < 0.001), GSH (p < 0.001), high-density lipoprotein (p < 0.01) levels and PON1 activity (p < 0.01), and significantly increased TOC, OSI (p < 0.001), MDA, NO, TSA, cholesterol, low-density lipoprotein (p < 0.01) and triglyceride (p < 0.05) levels. In conclusion, cotreatment with AS restored the negative effect of 3-NPA on all biochemical parameters cited above and improved the histopathological ovarian damage. Ovarian toxicity induced by 3-NPA might be due to oxidative damage. The improvement of AS seems to be related to its antioxidant properties.
Anahtar Kelimeler
3-nitropropionic acid | astaxanthin | ovarian damage | oxidative stress biomarkers | paraoxonase | sialic acid
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Dergi ISSN 1095-6670
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 03-2022
Cilt No 36
Sayı 3
Doi Numarası 10.1002/jbt.22966
Makale Linki http://dx.doi.org/10.1002/jbt.22966
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 10
Protective effect of astaxanthin on experimental ovarian damage in rats

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