The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice
Yazarlar (6)
Doç. Dr. Volkan GELEN Kafkas Üniversitesi, Türkiye
Emin Şengül Türkiye
Serkan Yıldırım Türkiye
Esra Şentürk Türkiye
Samet Tekin Türkiye
Dr. Öğr. Üyesi Abdulsamed KÜKÜRT Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (Q2) | ||
| Dergi ISSN | 0944-1344 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2021 |
| Cilt / Sayı / Sayfa | 28 / 34 / 47046–47055 | DOI | 10.1007/s11356-021-13969-5 |
| Makale Linki | http://dx.doi.org/10.1007/s11356-021-13969-5 | ||
| Özet |
| Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)-treated cancer patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in the pathogenesis of nephrotoxicity caused by 5-FU. In this study, protective effects of two natural compounds, hesperidin and curcumin, on experimentally induced kidney damage in mice with 5-FU were determined. Application of 5-FU resulted in severe histopathological changes and severe renal failure with increased serum urea and creatinine levels. Also, 5-FU-induced kidney damage, increased levels of malondialdehyde (MDA), decreased superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) activity, and glutathione (GSH) level have been demonstrated. Also, where 5-FU is in the concentration of caspase-3 and 8-OHdG immune-positive cells and therefore causes apoptosis and DNA damage in kidney tissue cells. However, especially high doses of hesperidin and curcumin treatment significantly improved 5-FU-induced oxidative stress/lipid peroxidation, apoptosis/DNA damage, and renal dysfunction. Based on these data, our results suggest that hesperidin and curcumin may be used as new and promising agents against 5-FU-induced nephrotoxicity. |
| Anahtar Kelimeler |
| Nephrotoxicity | Apoptosis | Curcumin | Hesperidin | Histopathology | Immunohistochemistry | Mice |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 59 |