| Yazarlar |
Dr. Öğr. Üyesi Volkan GELEN
Türkiye |
Emin Şengül
Türkiye |
|
Serkan Yıldırım
Türkiye |
|
Esra Şentürk
Türkiye |
|
Samet Tekin
Türkiye |
Dr. Öğr. Üyesi Abdulsamed KÜKÜRT
Kafkas Üniversitesi, Türkiye |
| Özet |
| Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)-treated cancer patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in the pathogenesis of nephrotoxicity caused by 5-FU. In this study, protective effects of two natural compounds, hesperidin and curcumin, on experimentally induced kidney damage in mice with 5-FU were determined. Application of 5-FU resulted in severe histopathological changes and severe renal failure with increased serum urea and creatinine levels. Also, 5-FU-induced kidney damage, increased levels of malondialdehyde (MDA), decreased superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) activity, and glutathione (GSH) level have been demonstrated. Also, where 5-FU is in the concentration of caspase-3 and 8-OHdG immune-positive cells and therefore causes apoptosis and DNA damage in kidney tissue cells. However, especially high doses of hesperidin and curcumin treatment significantly improved 5-FU-induced oxidative stress/lipid peroxidation, apoptosis/DNA damage, and renal dysfunction. Based on these data, our results suggest that hesperidin and curcumin may be used as new and promising agents against 5-FU-induced nephrotoxicity. |
| Anahtar Kelimeler |
| Nephrotoxicity,Apoptosis,Curcumin,Hesperidin,Histopathology,Immunohistochemistry,Mice |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Environmental Science and Pollution Research |
| Dergi ISSN | 0944-1344 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2021 |
| Cilt No | 28 |
| Sayı | 33 |
| Sayfalar | 47046 / 47055 |
| Doi Numarası | 10.1007/s11356-021-13969-5 |
| Makale Linki | http://dx.doi.org/10.1007/s11356-021-13969-5 |
| Atıf Sayıları | |
| WoS | 30 |
