| Yazarlar (8) |
Esra Çiftçi
Türkiye |
Doç. Dr. Murat BEYTUR
Kafkas Üniversitesi, Türkiye |
|
Mustafa Calapoğlu
Süleyman Demirel Üniversitesi, Türkiye |
|
Özlem Gürsoy Kol
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Muzaffer ALKAN
Kafkas Üniversitesi, Türkiye |
|
Vehbi Atahan Toğay
Türkiye |
Doç. Dr. Sevda MANAP
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Haydar YÜKSEK
Kafkas Üniversitesi, Türkiye |
| Özet |
| In this study, nine novel 2-[3-alkyl(aryl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl] phenoxyacetic acids (2) were obtained by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with 2-formylphenoxy acetic acid. Their structures were characterized by using H-1-NMR, C-13-NMR and IR spectral data together with elemental analysis. The synthesized novel compounds were analyzed for their in vitro antioxidant activity methods such as reducing power, free radical scavenging and metal chelating activity. Besides, agar hole methods were used to investigate the antibacterial properties of the 2 type compounds against the strains of B. subtilis, B. cereus, P. aeruginosa, K. Pneumoniae, S. aureus, and E. coli. Finally, the alkaline comet assay was used to investigate genotoxicity potential of the synthesized compounds in the peripheral blood lymphocytes (PBLs). |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | Research Journal of Pharmaceutical, Biological and Chemical Sciences |
| Dergi ISSN | 0975-8585 Scopus Dergi |
| Dergi Tarandığı Indeksler | E-SCI, CAS, Google scholar, EMBASE |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2018 |
| Cilt No | 9 |
| Sayı | 5 |
| Sayfalar | 1760 / 1771 |
