Synthesis, Characterization, Antioxidant and Antimicrobial Activities and DNA Damage of Some Novel 2-[3-alkyl (aryl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl]-phenoxyacetic acids in Human Lymphocytes
Yazarlar (8)
Esra Çiftçi
Türkiye
Doç. Dr. Murat BEYTUR
Kafkas Üniversitesi, Türkiye
Mustafa Calapoğlu
Süleyman Demirel Üniversitesi, Türkiye
Özlem Gürsoy Kol
Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN
Kafkas Üniversitesi, Türkiye
Vehbi Atahan Toğay
Türkiye
Doç. Dr. Sevda MANAP
Kafkas Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK
Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Research Journal of Pharmaceutical, Biological and Chemical Sciences | ||
| Dergi ISSN | 0975-8585 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | E-SCI, CAS, Google scholar, EMBASE | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2018 |
| Cilt / Sayı / Sayfa | 9 / 5 / 1760–1771 | DOI | – |
| Özet |
| In this study, nine novel 2-[3-alkyl(aryl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl] phenoxyacetic acids (2) were obtained by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with 2-formylphenoxy acetic acid. Their structures were characterized by using H-1-NMR, C-13-NMR and IR spectral data together with elemental analysis. The synthesized novel compounds were analyzed for their in vitro antioxidant activity methods such as reducing power, free radical scavenging and metal chelating activity. Besides, agar hole methods were used to investigate the antibacterial properties of the 2 type compounds against the strains of B. subtilis, B. cereus, P. aeruginosa, K. Pneumoniae, S. aureus, and E. coli. Finally, the alkaline comet assay was used to investigate genotoxicity potential of the synthesized compounds in the peripheral blood lymphocytes (PBLs). |
| Anahtar Kelimeler |
