Synthesis, Spectroscopic Analysis, and in Vitro/in Silico Biological Studies of Novel Piperidine Derivatives Heterocyclic Schiff-Mannich Base Compounds
Yazarlar (8)
Dr. Öğr. Üyesi Songül BOY Kafkas Üniversitesi, Türkiye
Abdülmelik Aras Iğdır Üniversitesi, Türkiye
Fikret Türkan Iğdır Üniversitesi, Türkiye
Doç. Dr. Onur AKYILDIRIM Kafkas Üniversitesi, Türkiye
Doç. Dr. Murat BEYTUR Kafkas Üniversitesi, Türkiye
Halide Sedef Karaman
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Doç. Dr. Sevda MANAP Kafkas Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistry and Biodiversity (Q3) | ||
| Dergi ISSN | 1612-1872 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2021 |
| Cilt / Sayı / Sayfa | 18 / 12 / – | DOI | 10.1002/cbdv.202100433 |
| Makale Linki | http://dx.doi.org/10.1002/cbdv.202100433 | ||
| Özet |
| In the present study, 3‐substitued‐4‐(4‐hydroxybenzylidenamino)‐4,5‐dihydro‐1H‐1,2,4‐triazol‐5‐ones (S1‐8) were synthesized by treating 4‐hydroxybenzaldehyde (B) with eight different 3‐substitued‐4‐amino‐4,5‐dihydro‐1H‐1,2,4‐triazole‐5‐ones (T1‐8) in acetic acid medium, separately. The synthesized Schiff bases (S) were reacted with formaldehyde and secondary amine such as 4‐piperidinecarboxyamide to afford novel heterocyclic bases. 3‐Substitued‐4‐(4‐hydroxybenzylidenamino)‐4,5‐dihydro‐1H‐1,2,4‐triazol‐5‐ones (T) were treated with 4‐piperidinecarboxyamide in the presence of formaldehyde to synthesize eight new 1‐(4‐piperidinecarboxyamide‐1‐yl‐methyl)‐3‐substitued‐4‐(4‐hydroxybenzylidenamino)‐4,5‐dihydro‐1H‐1,2,4‐triazol‐5‐ones (M1‐8). The structure characterization of compounds was carried out using 1H‐NMR, IR, HR‐MS, and 13C‐NMR spectroscopic methods. The … |
| Anahtar Kelimeler |
| 4-piperidinecarboxyamide | docking study | heterocyclic bases | inhibitory activity | schiff base |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 38 |