Synthesis, Antioxidant and Antimicrobial Activities of Some 1-Acetyl-3-alkyl(aryl)-4-[4-(4-methylbenzoxy)benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones
Yazarlar (6)
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
Ebru Koca
Doç. Dr. Murat BEYTUR Kafkas Üniversitesi, Türkiye
Prof. Dr. Özlem Gürsoy Kol Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Fevzi AYTEMİZ Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Chemical and Pharmaceutical Research | ||
| Dergi ISSN | 0975-7384 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | EBSCO | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2016 |
| Cilt / Sayı / Sayfa | 8 / 7 / 905–911 | DOI | – |
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| 3-alkyl (aryl)-4-[4-(4-methylbenzoxy) benzylidenamino]-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (3a, b, d, e, g) reacted with acetic anhydride to afford correspondig 1-acetyl-3-alkyl (aryl)-4-[4-(4-methylbenzoxy) benzylidenamino]-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (4a, b, d, e, g). The newly synthesized compounds were characterized using by elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data. In addition, the synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods, including reducing power, free radical scavenging and metal chelating activity. Moreover, antibacterial activity of these five new compounds and eight recently reported 3-alkyl (aryl)-4-[4-(4-methylbenzoxy) benzylidenamino]-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (3a–h) were screened agaist seven bacteria such as Bacillus subtilis, Yersinia enterocolitca, Bacillus cereus, Staphylococcus aureus, Escherichia coli, Pasterulla multicida and Klebsiella pneumoniae. |
| Anahtar Kelimeler |
