| Yazarlar (7) |
Şule Bahçeci
Trabzon Üniversitesi, Türkiye |
|
Nuri Yıldırım
Karadeniz Teknik Üniversitesi, Türkiye |
Prof. Dr. Muzaffer ALKAN
Kafkas Üniversitesi, Türkiye |
|
Özlem Gürsoy Kol
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Sevda MANAP
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Murat BEYTUR
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Haydar YÜKSEK
Kafkas Üniversitesi, Türkiye |
| Özet |
| 1, 2, 4-Triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives are reported to possess a broad spectrum of biological activities such as antifungal, antimicrobial, hypoglycemic, antihypertensive, analgesic, antiviral, antiinflammatory, antitumor, antioxidant and anti-HIV properties [1–9]. In addition, several articles reporting the synthesis of some N-arylidenamino-4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives have been published [8, 9]. On the other hand, it is known that 1, 2, 4-triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one rings have weak acidic properties, so some 1, 2, 4-triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in non-aqueous solvents, and the pKa values of the compounds were determined [7–9].Furthermore, antioxidants are extensively studied for their capacity to protect organisms and cells from damage induced by oxidative stress. Scientists in various disciplines have become more interested in new compounds, either synthesized or obtained from natural sources, which could provide active components to prevent or reduce the impact of oxidative stress on cells [10]. Exogenous chemicals and endogenous metabolic processes in human body or in food system might produce highly reactive free radicals, especially oxygen derived radicals, which are capable of oxidizing biomolecules, resulting in cell death and issue damage. Oxidative damages play a significant |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayınlanan tam makale |
| Dergi Adı | The Pharmaceutical and Chemical Journal |
| Dergi ISSN | 2349-7092 |
| Dergi Tarandığı Indeksler | Chemical Abstracts Service, SCOPUS |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2017 |
| Cilt No | 4 |
| Sayı | 4 |
| Sayfalar | 91 / 101 |
