Investigation of Antioxidant, Biological and Acidic Properties of New 3-Alkyl(Aryl)-4-(3-acetoxy-4-methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones
Yazarlar (7)
Prof. Dr. Şule Bahçeci Trabzon Üniversitesi, Türkiye
Doç. Dr. Nuri Yıldırım Karadeniz Teknik Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Özlem Gürsoy Kol Kafkas Üniversitesi, Türkiye
Doç. Dr. Sevda MANAP Kafkas Üniversitesi, Türkiye
Doç. Dr. Murat BEYTUR Kafkas Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | The Pharmaceutical and Chemical Journal | ||
| Dergi ISSN | 2349-7092 | ||
| Dergi Tarandığı Indeksler | Chemical Abstracts Service, SCOPUS | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2017 |
| Cilt / Sayı / Sayfa | 4 / 4 / 91–101 | DOI | – |
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| 1, 2, 4-Triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives are reported to possess a broad spectrum of biological activities such as antifungal, antimicrobial, hypoglycemic, antihypertensive, analgesic, antiviral, antiinflammatory, antitumor, antioxidant and anti-HIV properties [1–9]. In addition, several articles reporting the synthesis of some N-arylidenamino-4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives have been published [8, 9]. On the other hand, it is known that 1, 2, 4-triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one rings have weak acidic properties, so some 1, 2, 4-triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in non-aqueous solvents, and the pKa values of the compounds were determined [7–9].Furthermore, antioxidants are extensively studied for their capacity to protect organisms and cells from damage induced by oxidative stress. Scientists in various disciplines have become more interested in new compounds, either synthesized or obtained from natural sources, which could provide active components to prevent or reduce the impact of oxidative stress on cells [10]. Exogenous chemicals and endogenous metabolic processes in human body or in food system might produce highly reactive free radicals, especially oxygen derived radicals, which are capable of oxidizing biomolecules, resulting in cell death and issue damage. Oxidative damages play a significant |
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