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Synthesis, In Vitro Antioxidant and Antimicrobial Activities of Some Novel 2-Methoxy-4-[(3-substitue-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]phenyl 2-methylbenzoate Derivatives    
Yazarlar (7)
Prof. Dr. Haydar YÜKSEK Prof. Dr. Haydar YÜKSEK
Kafkas Üniversitesi, Türkiye
Osman Kutanis
Türkiye
Gül Özdemir
Türkiye
Doç. Dr. Murat BEYTUR Doç. Dr. Murat BEYTUR
Kafkas Üniversitesi, Türkiye
Savaş Kara
Türkiye
Özlem Gürsoy Kol
Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Prof. Dr. Muzaffer ALKAN
Kafkas Üniversitesi, Türkiye
Devamını Göster
Özet
In the present study, nine novel 2-methoxy-4-[(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azonnethine)phenyl 2-methylbenzoates (4a-i) were synthesized from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2a-i) with 3-(2-methylbenzoxy)-4-methoxybenzaldehyde (3) by using triethylamine. Then, the acetylation reactions of compounds 4a-e and 4g were investigated and 5 type compounds synthesized. The structures of fifteen new compounds were established from IR, H-1 NMR, C-13 NMR, UV and mass spectral data. In addition, the synthesized new 4 and 5 type compounds were analyzed for their in vitro potential antioxidant activities in three different methods; including 1,1-diphhenlyl-2-picrylhydrazyl free radical (DPPH.) scavenging, reducing activity by Fe+3 - Fe+2 transformation and ferrous metal (Fe+2) chelating activities. Furthermore, the synthesized compounds were …
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayınlanan tam makale
Dergi Adı Research Journal of Pharmaceutical, Biological and Chemical Sciences
Dergi ISSN 0975-8585 Scopus Dergi
Dergi Tarandığı Indeksler Emerging Sources Citation Index - ESCI
Makale Dili İngilizce
Basım Tarihi 05-2018
Cilt No 9
Sayı 4
Sayfalar 501 / 512
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları

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