| Yazarlar (4) |
Özlem Aktaş Yokuş
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Murat BEYTUR
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Sevda MANAP
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Haydar YÜKSEK
Kafkas Üniversitesi, Türkiye |
| Özet |
| Determination of pKa values of the active constituent of certain pharmaceutical preparations is important because the distribution, transport behaviour, bonding to receptors, and contributions to the metabolic behaviour of the active constituent molecules depend on the ionization constant. It is known that 1, 2, 4-triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one rings have weak acidic properties, so that some 1, 2, 4-triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives were titrated potentiometrically with tetrabutyl ammonium hydroxide (TBAH) in non-aqueous solvents, and the pKa values of the compounds were determined. In this study, the first part of the study nine novel 3-alkyl (aryl)-4-[3-etoxy-4-(4-methoxybenzensulfonyloxy)-benzylidenamino]-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones were synthesized from the reactions of the corresponding 3-alkyl (aryl)-4-amino-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones with 2-ethoxy-4-formylphenyl 4-methoxybenzenesulfonate, which was obtained from the reaction of 3-ethoxy-4-hydroxybenzaldehyde with 4-methoxybenzensulfonyl chloride by using triethylamine. The new compounds synthesized were also characterized by using IR and 1H-NMR, 13C-NMR spectral data. The second part of the study, nine novel 3-alkyl (aryl)-4-[3-etoxy-4-(4-methoxybenzensulfonyloxy)-benzylidenamino]-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones were titrated potentiometrically with TBAH (tetrabutylammonium hydroxide) in four different non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetone and N, N-dimethylformamide) and graphs were drawn for all cases. The half notralization potentials and pKa values were … |
| Anahtar Kelimeler |
| Bildiri Türü | Tebliğ/Bildiri |
| Bildiri Alt Türü | Tam Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum) |
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum |
| Bildiri Dili | İngilizce |
| Kongre Adı | International Conference on Research in Education Science (ICRES 2018) |
| Kongre Tarihi | 28-04-2018 / 01-05-2018 |
| Basıldığı Ülke | Türkiye |
| Basıldığı Şehir | Marmaris/Muğla |
