Factors leading to dissemination of cutaneous anthrax: an international ID-IRI study
Yazarlar (21)
Umran Sumeyse Elbahr
Türkiye
Recep Tekin
Türkiye
Milan Papić
Türkiye
Nenad Pandak
Türkiye
Hakan Erdem
Türkiye
Fatma Kesmez Can
Türkiye
Saygın Nayman Alpat
Türkiye
Abdullah Umut Pekok
Türkiye
Filiz Pehlivanoğlu
Türkiye
Doç. Dr. Murat KARAMEŞE
Kafkas Üniversitesi, Türkiye
Corneliu Petru Popescu
Türkiye
Sholpan Kulzhanova
Türkiye
Selma Tosun
Türkiye
Mustafa Doğan
Türkiye
Teresa Fasciana
Türkiye
Ruxandra Moroti
Türkiye
Ergys Ramosaco
Türkiye
Handan Alay
Türkiye
Edmond Puca
Türkiye
Jurica Arapovic
Türkiye
Natalia Pshenichnaya
Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | NEW MICROBES AND NEW INFECTIONS | ||
| Dergi ISSN | 2052-2975 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | E-SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2022 |
| Cilt / Sayı / Sayfa | 48 / 0 / 101028–0 | DOI | 10.1016/j.nmni.2022.101028 |
| Makale Linki | http://dx.doi.org/10.1016/j.nmni.2022.101028 | ||
| Özet |
| Although anthrax is a rare zoonotic infection, it still causes significant mortality and morbidity. In this multicenter study, which is the largest anthrax case series ever reported, we aimed to describe the factors leading to dissemination of cutaneous anthrax. Adult patients with cutaneous anthrax from 16 referral centers were pooled. The study had a retrospective design, and included patients treated between January 1, 1990 and December 1, 2019. Probable, and confirmed cases based upon CDC anthrax 2018 case definition were included in the study. A descriptive statistical analysis was performed for all variables. A total of 141 cutaneous anthrax patients were included. Of these, 105 (74%) patients had probable and 36 (26%) had confirmed diagnosis. Anthrax meningitis and bacteremia occurred in three and six patients, respectively. Sequelae were observed in three patients: cicatricial ectropion followed by ocular anthrax (n = 2) and movement restriction on the left hand after surgical intervention (n = 1). One patient had gastrointestinal anthrax. The parameters related to poor outcome (p < 0.05) were fever, anorexia, hypoxia, malaise/fatigue, cellulitis, fasciitis, lymphadenopathy, leukocytosis, high CRP and creatinine levels, longer duration of antimicrobial therapy, and combined therapy. The last two were seemingly the consequences of dissemination rather than being the reasons. The fatality rate was 1.4%. Rapid identification of anthrax is crucial for prompt and effective treatment. Systemic symptoms, disseminated local infection, and high inflammatory markers should alert the treating physicians for the dissemination of the disease. |
| Anahtar Kelimeler |
| Anthrax | Bacteremia | Gastrointestinal | Meningitis | Mortality | Outcome |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 3 |