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The relationship between adenovirus-36 seropositivity, obesity and metabolic profile in Turkish children and adults    
Yazarlar
Doç. Dr. Murat KARAMEŞE Doç. Dr. Murat KARAMEŞE
Kafkas Üniversitesi, Türkiye
Ülkü Altoparlak
Atatürk Üniversitesi, Türkiye
Alpgiray Turgut
Türkiye
Sabiha Aydoğdu
Hitit Üniversitesi, Türkiye
Prof. Dr. Selina AKSAK KARAMEŞE Prof. Dr. Selina AKSAK KARAMEŞE
Kafkas Üniversitesi, Türkiye
Özet
Obesity potentially arising from viral infection is known as 'infectobesity'. The latest reports suggest that adenovirus-36 (Adv36) is related to obesity in adults and children. Our aim was not only to determine the Adv36 seropositivity in both obese and non-obese children and adults, but also to investigate correlations between antibody positivity and serum lipid profiles. Both Adv36 positivity and tumour-necrosis-factor-alpha, leptin and interleukin-6 levels were detected in blood samples collected from 146 children and 130 adults by ELISA. Fasting plasma triglycerides, total cholesterol and low-density lipoprotein levels were also measured. Adv36 positivity was determined to be 27·1% and 6% in obese and non-obese children and 17·5% and 4% in obese and non-obese adults, respectively. There was no difference with regard to total cholesterol, low-density lipoprotein, triglyceride, tumour-necrosis-factor-alpha and interleukin-6 levels (P > 0·05). However, there was a significant difference between groups in terms of leptin levels (P < 0·05). We determined the prevalence of Adv36 positivity in obese children and adults. Our results showed that Adv36 may be an obesity agent for both adults and children, parallel with current literature data. However, the available data on a possible relationship between Adv36 infection and obesity both in children and adults do not completely solve the problem.
Anahtar Kelimeler
Adenovirus-36 | children | infectobesity | leptin
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı EPIDEMIOLOGY AND INFECTION
Dergi ISSN 0950-2688
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 12-2015
Cilt No 143
Sayı 16
Sayfalar 3550 / 3556
Doi Numarası 10.1017/S0950268815000679
Makale Linki https://www.cambridge.org/core/product/identifier/S0950268815000679/type/journal_article