Substituted naphthoxy-phthalonitrile derivatives: Synthesis, substituent effects, DFT, TD-DFT Calculations, antimicrobial properties and DNA interaction studies
Yazarlar (3)
Doç. Dr. Musa ERDOĞAN Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ceren Başkan Amasya Üniversitesi, Türkiye
Prof. Dr. Goncagül Serdaroğlu Sivas Cumhuriyet Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Computational Biology and Chemistry (Q2) | ||
| Dergi ISSN | 1476-9271 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2023 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-02-2023 |
| Cilt / Sayı / Sayfa | 102 / 1 / 107798–0 | DOI | 10.1016/j.compbiolchem.2022.107798 |
| Makale Linki | http://dx.doi.org/10.1016/j.compbiolchem.2022.107798 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Herein, substituted-naphthol derivatives 4a–e were synthesized in two steps, namely the Diels Alder cycloaddition and Cu-catalyzed aromatization reactions, respectively. Then, pththalonitrile derivatives 7–12 have been prepared by a nucleophilic displacement reaction of 3-nitrophthalonitrile with the naphthol derivatives 4a-e, 5 and, obtained in excellent yields. Structural characterization of the compounds was identified by different spectroscopic techniques. Antimicrobial properties of the synthesized compounds were determined by the microdilution procedure against Gram-positive, Gram-negative bacteria, and yeast. Furthermore, the DNA interaction of the compounds were determined by gel electrophoresis. One of the most prominent findings is that compounds 9 and 10 have more inhibitory effects on Gram-positive bacteria than Gram-negative bacteria. These compounds especially exhibited the highest … |
| Anahtar Kelimeler |
| Antimicrobial properties | DFT and TD-DFT studies | Phthalonitrile |
Science Direct
Substituted naphthoxy-phthalonitrile derivatives: Synthesis, substituent effects, DFT, TD-DFT Calculations, antimicrobial properties and DNA interaction studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 8 |
| Google Scholar | 7 |