Synthesis and docking calculations of tetrafluoronaphthalene derivatives and their inhibition profiles against some metabolic enzymes
Yazarlar (3)
Doç. Dr. Musa ERDOĞAN Kafkas Üniversitesi, Türkiye
Doç. Dr. Parham Taslımı Bartin Üniversitesi, Türkiye
Prof. Dr. Burak Tüzün Cumhuriyet Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Archiv Der Pharmazie (Q2) | ||
| Dergi ISSN | 0365-6233 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2021 |
| Kabul Tarihi | 05-02-2021 | Yayınlanma Tarihi | 05-03-2021 |
| Cilt / Sayı / Sayfa | 354 / 6 / 2000409–0 | DOI | 10.1002/ardp.202000409 |
| Makale Linki | http://dx.doi.org/10.1002/ardp.202000409 | ||
| UAK Araştırma Alanları |
Organik Kimya
|
||
| Özet |
| Syntheses of tetrahydroepoxy, O‐allylic, O‐prenylic, and O‐propargylic tetrafluoronaphthalene derivatives, starting from 1‐bromo‐2,3,4,5,6‐pentafluorobenzene, are reported here for the first time. The O‐substituted tetrafluoronaphthalene derivatives were designed and also synthesized via a one‐pot nucleophilic substitution reaction in excellent yields, whereas the tetrafluorotetrahydroepoxynaphthalene derivate was synthesized via a reduction reaction in excellent yield. The chemical structures of all the synthesized molecules were characterized by nuclear magnetic resonance, infrared spectroscopy, and high‐resolution mass spectrometry techniques. In this study, a series of novel tetrafluoronaphthalene derivatives (2, 2a, 4–6) was tested toward several enzymes including α‐glucosidase, acetylcholinesterase (AChE), and human carbonic anhydrase I and II (hCA I/II). The tetrafluoronaphthalene derivatives 2, 2a … |
| Anahtar Kelimeler |
| enzyme inhibition | molecular docking | O-allyl | O-prenyl | O-propargyl | tetrafluoronaphthalene |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 19 |
| Google Scholar | 25 |