Synthesis and biological evaluation of some 1-naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors
Yazarlar (4)
Doç. Dr. Musa ERDOĞAN Kafkas Üniversitesi, Türkiye
Leyla Polat Köse T.C. Beykent Üniversitesi, Türkiye
Selçuk Eşsiz Atatürk Üniversitesi, Türkiye
İlhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Archiv Der Pharmazie (Q2) | ||
| Dergi ISSN | 0365-6233 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2021 |
| Cilt / Sayı / Sayfa | 354 / 8 / 2100113–0 | DOI | 10.1002/ardp.202100113 |
| Makale Linki | http://dx.doi.org/10.1002/ardp.202100113 | ||
| Özet |
| A series of some naphthol derivatives 4a–f, 5a,f, 6a, and 7a,b (six novel ones: 4c,d, 5a, 6a, 7a,b) bearing F, Cl, Br, OMe, and dioxole substituents at different positions of the aromatic rings was designed, synthesized, and characterized. The naphthol derivatives were synthesized in three steps, namely the addition reaction of furan via Diels–Alder cycloaddition reaction, copper(II) trifluoromethanesulfonate (Cu(OTf)2)‐catalyzed aromatization reaction, and the bromination reaction, respectively. The structures of the newly obtained compounds (4c,d, 5a, 6a, 7a,b) were characterized by spectroscopic techniques. In addition, some biological activity studies were investigated under in vitro conditions. Inhibition studies of these compounds were performed on human carbonic anhydrase (hCA) I and II isoenzymes purified from human erythrocytes as a biological evaluation. Moreover, their potential antioxidant and … |
| Anahtar Kelimeler |
| 1-naphthols | acetylcholinesterase | antioxidant activity | carbonic anhydrase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 49 |
| Scopus | 43 |