Synthesis of N-substituted dibenzoazepine–pyridazine derivatives as potential neurologically active drugs
Yazarlar (2)
Doç. Dr. Musa ERDOĞAN
Kafkas Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Synthetic Communications |
| Dergi ISSN | 0039-7911 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2020 |
| Cilt No | 50 |
| Sayı | 24 |
| Sayfalar | 3845 / 3853 |
| DOI Numarası | 10.1080/00397911.2020.1828925 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/00397911.2020.1828925 |
| Özet |
| Syntheses of pyridazine derivatives of dibenzoazepine, starting from N-substituted-dibenzoazepines, are reported here for the first time. In the reaction sequence, N-substitute dibenzoazepine derivatives were synthesized and then, examined inverse electron demand Diels–Alder (IEDDA) reactions between N-substituted dibenzoazepine derivatives and tetrazines. While in some reactions, targeted products were obtained using phenyliodo-bis(trifluoroacetate) (PIFA), in other reactions, they were obtained directly with tetrazines which also behaved as the oxidizing agent. Structures of these compounds were fully characterized by NMR, IR, and HRMS spectroscopic techniques. |
| Anahtar Kelimeler |
| 5H-dibenzo[b,f]azepine | Azepine | iminostilbene | inverse electron demand Diels–Alder | PIFA | pyridazine | tetrazine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 8 |
| Google Scholar | 10 |
| Google Scholar | 7 |