Synthesis of N-substituted dibenzoazepine–pyridazine derivatives as potential neurologically active drugs
Yazarlar (2)
Doç. Dr. Musa ERDOĞAN
Kafkas Üniversitesi, Türkiye
Arif Daştan
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Synthetic Communications | ||
| Dergi ISSN | 0039-7911 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2020 |
| Cilt / Sayı / Sayfa | 50 / 24 / 3845–3853 | DOI | 10.1080/00397911.2020.1828925 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/00397911.2020.1828925 | ||
| Özet |
| Syntheses of pyridazine derivatives of dibenzoazepine, starting from N-substituted-dibenzoazepines, are reported here for the first time. In the reaction sequence, N-substitute dibenzoazepine derivatives were synthesized and then, examined inverse electron demand Diels–Alder (IEDDA) reactions between N-substituted dibenzoazepine derivatives and tetrazines. While in some reactions, targeted products were obtained using phenyliodo-bis(trifluoroacetate) (PIFA), in other reactions, they were obtained directly with tetrazines which also behaved as the oxidizing agent. Structures of these compounds were fully characterized by NMR, IR, and HRMS spectroscopic techniques. |
| Anahtar Kelimeler |
| 5H-dibenzo[b,f]azepine | Azepine | iminostilbene | inverse electron demand Diels–Alder | PIFA | pyridazine | tetrazine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 8 |
| Google Scholar | 10 |
| Google Scholar | 7 |