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Synthesis of N-substituted dibenzoazepine–pyridazine derivatives as potential neurologically active drugs       
Yazarlar
Doç. Dr. Musa ERDOĞAN Doç. Dr. Musa ERDOĞAN
Kafkas Üniversitesi, Türkiye
Arif Daştan
Atatürk Üniversitesi, Türkiye
Özet
Syntheses of pyridazine derivatives of dibenzoazepine, starting from N-substituted-dibenzoazepines, are reported here for the first time. In the reaction sequence, N-substitute dibenzoazepine derivatives were synthesized and then, examined inverse electron demand Diels–Alder (IEDDA) reactions between N-substituted dibenzoazepine derivatives and tetrazines. While in some reactions, targeted products were obtained using phenyliodo-bis(trifluoroacetate) (PIFA), in other reactions, they were obtained directly with tetrazines which also behaved as the oxidizing agent. Structures of these compounds were fully characterized by NMR, IR, and HRMS spectroscopic techniques.
Anahtar Kelimeler
5H-dibenzo[b,f]azepine | Azepine | iminostilbene | inverse electron demand Diels–Alder | PIFA | pyridazine | tetrazine
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı SYNTHETIC COMMUNICATIONS
Dergi ISSN 0039-7911
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 12-2020
Cilt No 50
Sayı 24
Sayfalar 3845 / 3853
Doi Numarası 10.1080/00397911.2020.1828925
Makale Linki https://www.tandfonline.com/doi/full/10.1080/00397911.2020.1828925