| Yazarlar |
Doç. Dr. Mustafa MAKAV
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Mushap KURU
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Şükran YEDİEL ARAS
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Ebru KARADAĞ SARI
Kafkas Üniversitesi, Türkiye |
Menekşe Bulut
Iğdır Üniversitesi, Türkiye |
|
Dureyt Veziroğlu
Iğdır Üniversitesi, Türkiye |
| Özet |
| Research question: What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)? Design: Female rats were divided into four groups, each consisting of eight animals. The control group received a carboxymethyl cellulose (CMC) solution, the molecular hydrogen (H2) group was given hydrogen-rich water and a CMC solution, the PCOS group was administered letrozole dissolved in a CMC solution and the PCOS + H2 group was given hydrogen-rich water and letrozole dissolved in a CMC solution. Blood and tissue samples were then collected, and biochemical and histopathological analyses were conducted on the samples. Results: The histopathological analysis showed a reduction in the number of cysts in the PCOS + H2 group compared with the PCOS group (P < 0.0001). Additionally, the malondialdehyde, cortisol and testosterone data revealed a significant decrease in the PCOS + H2 group compared with the PCOS group (P = 0.0458, P = 0.0003, P = 0.0041, respectively). The glutathione also showed a statistically significant increase in the PCOS + H2 group compared with the PCOS group (P = 0.0012). Conclusion: The study findings demonstrate that hydrogen-rich water reduces the number of cysts and oxidative damage in rats with PCOS. |
| Anahtar Kelimeler |
| polycystic ovary syndrome | malondialdehyde | glutathione | hydrogen rich water | rats |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | REPRODUCTIVE BIOMEDICINE ONLINE |
| Dergi ISSN | 1472-6483 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2023 |
| Cilt No | 47 |
| Sayı | 6 |
| Sayfalar | 103332 / 0 |
| Doi Numarası | 10.1016/j.rbmo.2023.103332 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S1472648323004327?dgcid=coauthor |
| Atıf Sayıları | |
| WoS | 2 |
| SCOPUS | 2 |
| Google Scholar | 5 |
