| Yazarlar (8) |
Doç. Dr. Mustafa SERTÇELİK
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Füreya Elif ÖZTÜRKKAN
Kafkas Üniversitesi, Türkiye |
Parham Taslimi
Bartin Üniversitesi, Türkiye |
|
Murat Durman
Ankara Üniversitesi, Türkiye |
|
Mücahit Özdemir
Marmara Üniversitesi, Türkiye |
|
Tuncer Hökelek
Hacettepe Üniversitesi, Türkiye |
|
Bahattin Yalçın
Marmara Üniversitesi, Türkiye |
Prof. Dr. Hacali NECEFOĞLU
Kafkas Üniversitesi, Türkiye |
| Özet |
| A novel Ni(II) complex containing 2-fluorobenzoate and 3-hydroxypyridine ligands was synthesized and characterized using elemental analysis, Fourier transform infrared (FT-IR) spectroscopy and single-crystal X-ray diffraction. FT-IR peaks show that the carboxylate group from 2-fluorobenzoate has a monodentate coordination mode. The coordination environment around the Ni2+ ion is of distorted octahedral geometry. The octahedral geometry consists of a total of four oxygen atoms from two carboxylate groups of two fluorobenzoate anions, two water molecules and two nitrogen atoms from two 3-hydroxypyridine ligands. The complex shows excellent inhibitory effects against some metabolic enzymes. Ki values for the complex were found as 108.17 ± 25.63, 124.88 ± 36.20, 28.11 ± 2.87, 20.95 ± 5.65 and 32.63 ± 9.67 μM against human carbonic anhydrase I, human carbonic anhydrase II, α-glycosidase, acetylcholinesterase and butyrylcholinesterase, respectively. In addition, geometry optimization and vibration frequencies were calculated, and single point energy was studied based on optimization. Experimental and theoretical data were compared. The B3LYP/6-31G(d,p) basis set was used for all calculations. |
| Anahtar Kelimeler |
| 2-fluorobenzoate | 3-hydroxypyridine | DFT calculation | metabolic enzyme inhibition | XRD |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Applied Organometallic Chemistry |
| Dergi ISSN | 0268-2605 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2020 |
| Cilt No | 34 |
| Sayı | 9 |
| Sayfalar | 1 / 10 |
| Doi Numarası | 10.1002/aoc.5802 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/abs/10.1002/aoc.5802 |
| Atıf Sayıları | |
| SCOPUS | 8 |
| Google Scholar | 8 |
