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Changes in genotoxicity, inflammatory and oxidative stress parameters of workers in marble processing plants     
Yazarlar
Merve Becit Kızılkaya
Türkiye
Şule Çilekar
Türkiye
Doç. Dr. Mustafa Mert BAŞARAN Doç. Dr. Mustafa Mert BAŞARAN
Türkiye
Halit Buğra Koca
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye
Sefa Çelik
Türkiye
Sevtap Aydın Dilsiz
Türkiye
Özet
Workers in marble processing plants are at high risk of exposure to high levels of marble dust containing silica, but there are limited studies evaluating the genotoxicity and oxidative stress parameters of workers occupationally exposed to marble dust. In this study, we aimed to clarify how marble dust affects genotoxicity and immunotoxicity mechanisms alongside oxidative stress in the workers in the marble processing plants of Iscehisar, Turkey. The oxidative stress and immune system parameters were determined spectrophotometrically using commercial kits. Genotoxicity was evaluated by Comet and micronucleus (MN) assays in the lymphocytes and buccal cells, respectively. The enzyme activities of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and the levels of glutathione, and Clara cell secretory protein CC16 in workers (n = 48) were significantly lower than in controls (n = 41), whereas the levels of malondialdehyde, 8-oxo-7,8-dihydro-2'-deoxyguanosine, tumor necrosis factor-alpha, interleukin-1beta were significantly higher in workers. DNA damage in workers were significantly higher than in controls and there was a clear correlation between the increase in DNA damage and the duration of exposure. Marble workers had significantly higher MN frequencies when compared to controls. The results indicate the possibility of immunotoxic and genotoxic risks to workers in marble industry.
Anahtar Kelimeler
Marble dust | Occupational exposure | Oxidative stress | DNA damage | Micronucleus
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı ENVIRONMENTAL RESEARCH
Dergi ISSN 0013-9351
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili İngilizce
Basım Tarihi 06-2021
Cilt No 197
Sayı 111209
Sayfalar 1 / 10
Doi Numarası 10.1016/j.envres.2021.111209
Makale Linki http://dx.doi.org/10.1016/j.envres.2021.111209