| Yazarlar |
Dr. Öğr. Üyesi Mustafa Mert BAŞARAN
Kafkas Üniversitesi, Türkiye |
Merve Hazar
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Mehtap Aydın
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Gülsüm Uzuğ
Türkiye |
|
Lkima Özdoğan
Türkiye |
|
Emin Pala
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Sevtap Aydın Dilsiz
Hacettepe Üniversitesi, Türkiye |
|
Ayşe Nurşen Başaran
Başkent Üniversitesi, Türkiye |
| Özet |
| Coronavirus disease 2019 (COVID-19) has posed a great threat to public health and has caused concern due to its fatal consequences over the last few years. Most people with COVID-19 show mild-to-moderate symptoms and recover without the need for special treatment, while others become seriously ill and need medical attention. Additionally, some serious outcomes, such as heart attacks and even stroke, have been later reported in patients who had recovered. There are limited studies on how SARS-CoV-2 infection affects some molecular pathways, including oxidative stress and DNA damage. In this study, we aimed to evaluate DNA damage, using the alkaline comet assay, and its relationship with oxidative stress and immune response parameters in COVID-19-positive patients. Our results show that DNA damage, oxidative stress parameters and cytokine levels significantly increased in SARS-CoV-2-positive patients when compared with healthy controls. The effects of SARS-CoV-2 infection on DNA damage, oxidative stress and immune responses may be crucial in the pathophysiology of the disease. It is suggested that the illumination of these pathways will contribute to the development of clinical treatments and to reduce adverse effects in the future. |
| Anahtar Kelimeler |
| SARS-CoV-2 infection,COVID-19,DNA damage,oxidative stress |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Toxics |
| Dergi ISSN | 2305-6304 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2023 |
| Cilt No | 11 |
| Sayfalar | 1 / 14 |
| Doi Numarası | 10.3390/toxics11040386 |
| Makale Linki | http://dx.doi.org/10.3390/toxics11040386 |
| Atıf Sayıları | |
| WoS | 6 |
