Effects of COVID-19 Disease on DNA Damage, Oxidative Stress and Immune Responses
Yazarlar (8)
Doç. Dr. Mustafa Mert BAŞARAN
Kafkas Üniversitesi, Türkiye
Merve Hazar
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Mehtap Aydın
Sağlık Bilimleri Üniversitesi, Türkiye
Gülsüm Uzuğ
Lkima Özdoğan
Emin Pala
Sağlık Bilimleri Üniversitesi, Türkiye
Sevtap Aydın Dilsiz
Hacettepe Üniversitesi, Türkiye
Ayşe Nurşen Başaran
Başkent Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | TOXICS (Q1) | ||
| Dergi ISSN | 2305-6304 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2023 |
| Cilt / Sayı / Sayfa | 11 / 4 / 1–14 | DOI | 10.3390/toxics11040386 |
| Makale Linki | http://dx.doi.org/10.3390/toxics11040386 | ||
| Özet |
| Coronavirus disease 2019 (COVID-19) has posed a great threat to public health and has caused concern due to its fatal consequences over the last few years. Most people with COVID-19 show mild-to-moderate symptoms and recover without the need for special treatment, while others become seriously ill and need medical attention. Additionally, some serious outcomes, such as heart attacks and even stroke, have been later reported in patients who had recovered. There are limited studies on how SARS-CoV-2 infection affects some molecular pathways, including oxidative stress and DNA damage. In this study, we aimed to evaluate DNA damage, using the alkaline comet assay, and its relationship with oxidative stress and immune response parameters in COVID-19-positive patients. Our results show that DNA damage, oxidative stress parameters and cytokine levels significantly increased in SARS-CoV-2-positive patients when compared with healthy controls. The effects of SARS-CoV-2 infection on DNA damage, oxidative stress and immune responses may be crucial in the pathophysiology of the disease. It is suggested that the illumination of these pathways will contribute to the development of clinical treatments and to reduce adverse effects in the future. |
| Anahtar Kelimeler |
| SARS-CoV-2 infection | COVID-19 | DNA damage | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 11 |