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Efficiency of hypericum perforatum, povidone iodine, tincture benzoin and tretinoin on wound healing      
Yazarlar
Esin Yalçınkaya
Türkiye
Doç. Dr. Mustafa Mert BAŞARAN Doç. Dr. Mustafa Mert BAŞARAN
Türkiye
Mehmet Emin Tunçkaşık
Türkiye
Gülce Naz Yazıcı
Erzincan Binali Yıldırım Üniversitesi, Türkiye
Çiğdem Elmas
Türkiye
Sinan Kocatürk
Türkiye
Özet
Different topical agents have been used to accelerate wound healing. The purpose of this study is to compare the safety and efficacy of topical application of the extract of Hypericum perforatum (HPE), povidone iodine (PI), tincture benzoin (TB) and tretinoin (T) on surgical wound healing. Ten adult female, Wistar albino rats were included in the study. HPE, PI, TB and T solutions were applied on the wounds. After seven days, tissue samples were collected and inflammatory cells, re-epithelialization, granulation tissue, angiogenesis, collagen accumulation, hemorrhage and lysis of cells were investigated histopathologically. No dermal toxicity was noted. HPE, TB, PI have all showed good epithelialization and granulation, but HPE showed the most advanced stage of healing within a short period of time. HPE had significantly higher values of re-epithelialization and collagen accumulation, but lower inflammatory cell count and granulation tissue. TB had the second best in re-epithelialization, collagen accumulation and the highest granulation tissue. PI induced better reepithelialization and granulation than the control group with remarkable cell lysis. As a result, HPE can be a safe, effective, and cheap agent that can be used for surgical wounds.
Anahtar Kelimeler
Hypericum perforatum | Povidone iodine | Tincture benzoin | Tretinoin | Wound healing
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı FOOD AND CHEMICAL TOXICOLOGY
Dergi ISSN 0278-6915
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili İngilizce
Basım Tarihi 08-2022
Cilt No 166
Sayı 166
Sayfalar 1 / 9
Doi Numarası 10.1016/j.fct.2022.113209
Makale Linki https://www.sciencedirect.com/science/article/pii/S0278691522004070?via%3Dihub