Synthesis and investigations of antimicrobial, antioxidant activities of novel di-[2-(3-alkyl/ aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethinephenyl] isophtalates and mannich base derivatives
Yazarlar (7)
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
Gül Özdemir
Doç. Dr. Sevda MANAP Kafkas Üniversitesi, Türkiye
Yonca Yılmaz
Doç. Dr. Gül KOTAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Özlem Gürsoy Kol Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | ACTA Pharmaceutica Sciencia | ||
| Dergi ISSN | 2636-8552 | ||
| Dergi Tarandığı Indeksler | CAS, Scopus, Open Access, Focus | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2020 |
| Cilt / Sayı / Sayfa | 58 / 1 / 49–68 | DOI | 10.23893/1307-2080.APS.05804 |
| Makale Linki | http://dx.doi.org/10.23893/1307-2080.aps.05804 | ||
| UAK Araştırma Alanları |
Organik Kimya
|
||
| Özet |
| In this study, the synthesis of di-[2-(3-alkyl/aryl-4, 5-dihydro-1H-1, 2, 4-triazol-5-one-4-yl)-azomethinephenyl] isophtalates (2a-g) from the reactions of 3-alkyl/aryl-4-amino-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (1a-g) with di-(2-formylphenyl) isophtalate is described. Then, the compounds 2 were treated with morpholine in the presence of formaldehyde to synthesize di-{2-[1-(morpholine-4-yl-methyl)-3-alkyl (aryl)-4, 5-dihydro-1H-1, 2, 4-triazol-5-one-4-yl]-azomethinephenyl} isophtalates (3a-g). The newly synthesized compounds were characterized using IR, 1H-NMR and 13C-NMR spectral data. In addition, the compounds synthesized were screened for their antimicrobial activities. Furthermore, the antioxidant properties of the newly synthesized compounds were analysed for their in-vitro potential antioxidant activities in three different methods (reducing power, free radical scavenging and metal chelating activity). These antioxidant activities were compared to those from standard antioxidants, such as BHA, BHT, EDTA and α-tocopherol. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 12 |